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the claim

Higher levels of systemic inflammation are associated with a greater risk of major depression in adults.

the verdict
INSUFFICIENT LEANING
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that higher levels of systemic inflammation are associated with a greater risk of major depression in adults?

Unclear. Three placed sources report positive associations between inflammatory markers and depression, but each covers only a narrow population: depressed patients versus controls, older adults with comorbid sleep apnea, and adults with diabetes. None establishes the general claim that higher systemic inflammation raises major depression risk in adults.

Verdict: PARTIAL LEAN · 3 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 3
Frontiers | The correlation between systemic immune-inflammation index and major depression in patients with depression
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Frontiers | The correlation between systemic immune-inflammation index and major depression in patients with depression. (n.d.). frontiersin.org. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1580151/full

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More for · 2
Impact of C-reactive protein-triglyceride-glucose and systemic immune-inflammation indices on obstructive sleep apnea in older adults with depression.
2026
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S, H., J, Z., S, X., Z, L., & S, Z. (2026). Impact of C-reactive protein-triglyceride-glucose and systemic immune-inflammation indices on obstructive sleep apnea in older adults with depression.. doi.org. https://doi.org/10.3389/fnins.2026.1821053

Associations between inflammation and depressive symptoms in diabetes: A scoping review.
2026
Get citation
NJ, S., JC, F., & SJ, F. (2026). Associations between inflammation and depressive symptoms in diabetes: A scoping review.. doi.org. https://doi.org/10.1177/14791641261476326

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