Hereditary cancer risk can be accurately estimated using genetic and family history models.
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Multiple clinical and genetic studies demonstrate that hereditary cancer risk can be effectively estimated using combined genetic models, polygenic risk scores, and family history data.
Evidence for · 10
Breast MRI texture analysis for prediction of BRCA-associated genetic risk
2020 · cited by 13
Demonstrates that combining genetic factors, imaging, and family cancer history effectively predicts hereditary breast cancer risk.
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More for · 9
Clinical Impact of Polygenic Risk Score for Breast Cancer Risk Prediction in 382 Individuals with Hereditary Breast and Ovarian Cancer Syndrome
2023 · cited by 8
Shows that incorporating polygenic risk scores into standard genetic testing improves breast cancer risk stratification and clinical recommendations.
Validation of a Clinical and Polygenic Risk Prediction Model for Ovarian Cancer in the Nurses' Health Study.
2026 · cited by 1
Validates a combined clinical and polygenic risk prediction model for ovarian cancer screening and prevention.
Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.
2026 · cited by 1
Indicates that both family history and polygenic risk scores are significantly associated with disease risk and enhance risk stratification when integrated.
Polygenic risk scores in cancer.
2026 · cited by 0
Notes that polygenic risk scores refine cancer risk prediction beyond family history and age across multiple cancer types.
Evaluating a Mendelian Risk Prediction Model That Aggregates Across Genes and Cancers.
2026 · cited by 0
Evaluates Mendelian risk prediction models that aggregate across genes and family histories to accurately identify heritable cancer susceptibility.
Performance of LFSPRO prediction in TP53 mutation status for prospectively collected probands.
2026 · cited by 0
Demonstrates that family-history-based Mendelian models like LFSPRO provide strong discriminatory performance in predicting hereditary cancer risk.
Web-Based User Interface for Fam3PRO: A Multigene, Multicancer Risk Prediction Model for Families With Cancer History.
2026 · cited by 0
Presents validated multigene, multicancer Mendelian models that estimate patient risk of carrying pathogenic variants based on family history and genetic factors.
Clinical predictors of <i>BRCA1/2</i> P/LP variants for high-risk breast cancer patients in China: <i>HBRCA-risk prediction</i>.
2026 · cited by 0
Shows that clinicopathology-based models incorporating family history and genetic markers effectively predict hereditary breast cancer risk in clinical cohorts.
Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.
2026 · cited by 0
Evaluates polygenic risk scores alongside family history to provide accurate breast cancer risk stratification in diverse populations.