Gastroesophageal reflux disease (GERD) is traditionally understood through an acid-centric model where excessive gastric acid or reflux causes mucosal injury, and treatments focus on acid suppression rather than low stomach acid.
Evidence against · 4
Lessons learned: use of 24-hour ambulatory esophageal and gastric pH monitoring and its implications for proton pump inhibitor use in cancer patients requiring oral oncologic therapies.
2026 · cited by 0
This paper discusses GERD and utilizes proton pump inhibitors to control esophageal acid reflux, aligning with the acid-centric mechanism of the condition rather than low stomach acid as a cause.
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More against · 3
Rethinking Long-Term PPI Therapy in GERD: A Narrative Review from a Microbial Ecology Perspective Beyond Acid Suppression.
2026 · cited by 0
This paper reviews GERD from an acid-centric model and notes that proton pump inhibitors remain the mainstay of therapy, contradicting the premise that low stomach acid causes the disorder.
Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update.
2026 · cited by 0
This review highlights that the primary treatment for GERD is the suppression of gastric acid via proton pump inhibitors, contradicting the claim that low acid causes GERD.
Zastaprazan, a Novel Potassium-Competitive Acid Blocker, for Acid-Related Disorders.
2026 · cited by 0
This review confirms that acid-related disorders like GERD are treated with acid-suppressive therapy, which works on the underlying hyperacidity model rather than hypochlorhydria.