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the claim

Finasteride increases the risk of high-grade prostate cancer.

the verdict
REFUTED
the evidence says no
Recorded sources
0 sources for · 4 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Finasteride increases the risk of high-grade prostate cancer?

No. A bias-adjusted reanalysis of the Prostate Cancer Prevention Trial reports that the apparent increase in high-grade prostate cancer with finasteride was attributable to detection bias, with adjusted estimates showing no significant increase (RR 1.14, 95% CI 0.96-1.35). Other placed items are partial: one shows the direction of the association depends on assumed biopsy sensitivity, and two concern dutasteride or genotype subgroups rather than finasteride's overall effect.

Verdict: REFUTED · 0 sources for, 4 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence against · 4
Finasteride Does Not Increase the Risk of High-Grade Prostate Cancer: A Bias-Adjusted Modeling Approach
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Finasteride Does Not Increase the Risk of High-Grade Prostate Cancer: A Bias-Adjusted Modeling Approach. (n.d.). cir.nii.ac.jp. https://doi.org/10.1158/1940-6207.capr-08-0092

2 recorded entries grouped as this source

Additional records of the same source are shown below. They are not counted as additional sources.

Finasteride Does Not Increase the Risk of High-grade Prostate Cancer: A Bias-adjusted Modeling Approach -
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Finasteride Does Not Increase the Risk of High-grade Prostate Cancer: A Bias-adjusted Modeling Approach - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1158/1940-6207.CAPR-08-0092

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More against · 3
Alcohol Intake Increases High-grade Prostate Cancer Risk Among Men Taking Dutasteride in the REDUCE Trial
2014
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Fowke, J., Howard, L., Andriole, G., & Freedland, S. (2014). Alcohol Intake Increases High-grade Prostate Cancer Risk Among Men Taking Dutasteride in the REDUCE Trial. doi.org. https://doi.org/10.1016/j.eururo.2014.01.037

Case-only Methods Identified Genetic Loci Predicting a Subgroup of Men with Reduced Risk of High-grade Prostate Cancer by Finasteride
2018
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Dai, J. Y., LeBlanc, M., Goodman, P., Lucia, M., Thompson, I., & Tangen, C. (2018). Case-only Methods Identified Genetic Loci Predicting a Subgroup of Men with Reduced Risk of High-grade Prostate Cancer by Finasteride. doi.org. https://doi.org/10.1158/1940-6207.CAPR-18-0284

Effect of Finasteride on Serum Androstenedione and Risk of Prostate Cancer within the Prostate Cancer Prevention Trial: Differential Effect on High and Low Grade Disease
2015
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Hoque, A., Yao, S., Till, C., Kristal, A., Goodman, P., Hsing, A., Tangen, C., Platz, E., Stanczyk, F., Reichardt, J., vanBokhoven, A., Neuhouser, M., Santella, R., Figg, W., Price, D., Parnes, H., Lippman, S., Ambrosone, C., & Thompson, I. (2015). Effect of Finasteride on Serum Androstenedione and Risk of Prostate Cancer within the Prostate Cancer Prevention Trial: Differential Effect on High and Low Grade Disease. doi.org. https://doi.org/10.1016/j.urology.2014.11.024

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