Mounting biomedical research demonstrates that fibromyalgia is associated with identifiable physiological causes, including central nervous system sensitization, neuroinflammation, immune dysregulation, oxidative stress, and gut microbiome alterations.
Evidence for · 7
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
2021 · cited by 645
Reviews pathogenesis mechanisms including central sensitization, inflammatory, immune, endocrine, and genetic factors.
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More for · 6
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
2018 · cited by 309
Provides in vivo PET imaging evidence supporting brain glial activation in fibromyalgia pathophysiology.
Passive transfer of fibromyalgia symptoms from patients to mice
2021 · cited by 273
Demonstrates that patient-derived IgG can passively transfer sensory hypersensitivity to mice, highlighting underlying immunological mechanisms.
Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis
2021 · cited by 126
Provides a systematic review and meta-analysis showing significant differences in circulating cytokine profiles in fibromyalgia patients compared to healthy controls.
Pathogenetic and clinical aspects of fibromyalgia: one year in review 2026.
2026 · cited by 0
Summarizes ongoing evidence for central sensitization, non-classical autoimmune mechanisms, gut microbiome alterations, and oxidative stress.
The microbiota-gut-brain axis in fibromyalgia: a scoping review.
2026 · cited by 0
Maps contemporary evidence implicating the microbiota-gut-brain axis as a biological contributor to fibromyalgia pathophysiology.
Fibromyalgia, Eating Disorders and Rehabilitation: The Nrf2 Link.
2026 · cited by 0
Identifies elevated oxidative stress markers and mitochondrial dysfunction linked to Nrf2 pathway dysregulation in fibromyalgia patients.