Female sex hormones influence the coagulation cascade to promote blood clotting
the verdict
CONTESTED
the evidence cuts both ways
confidence 20/100
The effect of female sex hormones on blood coagulation is complex and heavily dependent on the specific hormone formulation, route of administration, and patient context, leading to mixed findings regarding whether they promote clotting or favor fibrinolysis.
Evidence for · 4
Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis.
2017 · cited by 0
Reviews how combined oral contraceptives containing estrogens and progestins alter hemostasis and influence thrombotic risk.
Evidence against · 3
Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study.
2000 · cited by 0
Demonstrates that certain hormone therapies (tibolone) can shift hemostasis toward a more fibrinolytic profile without major coagulation activation.
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More for · 3
Impact of Estetrol Combined with Drospirenone on Blood Coagulation and Fibrinolysis in Patients with Endometriosis: A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study.
2024 · cited by 0
Shows that estrogen-containing combined hormone preparations affect coagulation and fibrinolysis cascades.
Oral contraception and coagulation.
1985 · cited by 0
Indicates that estrogen components in oral contraceptives elevate clotting factors and impact the coagulation mechanism.
The mechanisms of thrombotic risk induced by hormone replacement therapy.
2001 · cited by 0
Notes that sex hormone therapies can induce a procoagulant state by altering the coagulation cascade.
More against · 2
Effects of hormone replacement on hemostasis in spontaneous menopause.
2001 · cited by 0
Finds that specific hormone replacement therapies decreased certain coagulation factors and prolonged activated partial thromboplastin time.
Comparison of the effects of tibolone and estrogen therapy on hemostasis in surgical menopause: a randomized, double-blind, placebo-controlled study.
2007 · cited by 0
Indicates that certain therapies changed the overall hemostatic balance to a more fibrinolytic state rather than promoting clotting.