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Epigenetic marks are inherited across generations in mammals.
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CONTESTED PARTIAL
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5 sources for · 4 against
Is it true that epigenetic marks are inherited across generations in mammals?
Partly. Peer-reviewed reviews agree some epigenetic marks can occasionally escape reprogramming and be transmitted across generations in mammals, but they describe this as rare, controversial, or limited to specific loci and models. Other sources emphasize that mammalian epigenetic marks are typically reset during reproduction.
Verdict: CONTESTED PARTIAL · 5 sources for, 4 against · Last checked
Evidence for · 5
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epigenetics. (n.d.). cancer.gov. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/epigenetics
Evidence against · 4
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Feiner, N., Radersma, R., Vasquez, L., Ringnér, M., Nystedt, B., & Raine, A. (2022). Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species. doi.org. https://doi.org/10.1016/j.isci.2022.104303
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More for · 4
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Kaspar, D., Hastreiter, S., Irmler, M., Angelis, M. H. d., & Beckers, J. (2020). Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.. doi.org. https://doi.org/10.1007/s00335-020-09839-z
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A, A. M., V, S., J, K., A, W., LA, P., RS, A., K, H., & BJ, I. (2025). Transgenerational non-genomic transmission of acquired nervous system Phenotypes: Narrative review and epigenetic insights.. doi.org. https://doi.org/10.1016/j.neuint.2025.106088
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Intergenerational and transgenerational epigenetic mechanisms shaping livestock production and reproduction. (n.d.). cir.nii.ac.jp. https://doi.org/10.1262/jrd.2025-096
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Bellver-Sanchis, A., Pallàs, M., & Griñán-Ferré, C. (2021). The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease. doi.org. https://doi.org/10.3390/epigenomes5020015
More against · 3
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Frontiers | Transgenerational epigenetic inheritance: a critical perspective. (n.d.). frontiersin.org. https://www.frontiersin.org/journals/epigenetics-and-epigenomics/articles/10.3389/freae.2024.1434253/full
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Transgenerational epigenetic inheritance in farm animals: How substantial is the evidence?. (2021). doi.org. https://doi.org/10.1016/j.livsci.2021.104557
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Zheng, H., Huang, B., Zhang, B., Xiang, Y., Du, Z., Xu, Q., Li, Y., Wang, Q., Ma, J., Peng, X., Xu, F., & Xie, W. (2016). Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals.. doi.org. https://doi.org/10.1016/j.molcel.2016.08.032
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