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the claim

Endemic malaria and schistosomiasis are important causes of hepatosplenomegaly.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Endemic malaria and schistosomiasis are important causes of hepatosplenomegaly?

Yes. Both endemic malaria and schistosomiasis are well-documented parasitic infections that significantly contribute to hepatosplenomegaly and related hepatic and splenic morbidity.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers provide strong clinical and epidemiological evidence that both schistosomiasis (specifically S. mansoni) and malaria are major contributors to hepatosplenomegaly, liver fibrosis, and portal vein dilation in endemic regions.

Evidence for · 5
<i>Schistosoma Mansoni</i> and <i>Haematobium</i>: Radiological Diagnostic Clues and Pathophysiology.
2026
Schistosoma mansoni causes hepatic complications including periportal fibrosis, portal hypertension, and chronic liver disease.
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SA, A., AO, M., AH, A., RR, A., KM, A., KM, A., AM, H., FH, A., AA, Q., W, A., A, A., E, A., A, A., KA, A., & KM, A. (2026). <i>Schistosoma Mansoni</i> and <i>Haematobium</i>: Radiological Diagnostic Clues and Pathophysiology.. doi.org. https://doi.org/10.3390/pathogens15050536

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More for · 4
<i>Schistosoma mansoni</i> infections are associated with hepatosplenic organometry within the context of repeated praziquantel treatment and co-endemic infections of malaria, hepatitis B, and HIV: a population-based study in rural Uganda
2026
Population-based data demonstrate that Schistosoma mansoni intensity and malaria infections are major drivers of hepatosplenic organomegaly and severe splenomegaly.
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K, S., MM, L., B, N., V, A., B, N., T, M., S, M., NB, K., AD, S., & GF, C. (2026). <i>Schistosoma mansoni</i>  infections are associated with hepatosplenic organometry within the context of repeated praziquantel treatment and co-endemic infections of malaria, hepatitis B, and HIV: a population-based study in rural Uganda. doi.org. https://doi.org/10.64898/2026.03.06.26347797

The relationship between expelled eggs, morbidity and age in a Schistosoma mansoni endemic setting in Uganda: Implications for current elimination policies.
2025
Co-endemic malaria and schistosomiasis infections are linked to liver and splenic abnormalities such as portal vein dilation and organ enlargement.
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RM, L., R, L., J, C., M, A., V, A., S, A., A, N., F, B., A, A., AB, P., JP, W., & PHL, L. (2025). The relationship between expelled eggs, morbidity and age in a Schistosoma mansoni endemic setting in Uganda: Implications for current elimination policies.. doi.org. https://doi.org/10.1371/journal.pntd.0012750

The relationship between expelled eggs, morbidity and age: implications for current<i>Schistosoma mansoni</i>elimination policies
2024
Malaria and schistosomiasis contribute significantly to organometry changes and morbidity markers like portal vein dilation.
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RM, L., R, L., M, A., V, A., S, A., A, N., F, B., A, A., AB, P., JP, W., & PH, L. (2024). The relationship between expelled eggs, morbidity and age: implications for current<i>Schistosoma mansoni</i>elimination policies. doi.org. https://doi.org/10.1101/2024.12.04.24318477

Splenic shear wave elastography beyond portal hypertension: a narrative review of non-portal applications.
2026
Infectious diseases such as schistosomiasis are highlighted for causing microvascular and inflammatory changes leading to splenomegaly and hepatosplenic alterations.
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M, P., S, A., MS, L., S, M., G, D., E, M., N, V., F, d. P., F, M., FR, P., F, S., A, G., L, R., & M, G. (2026). Splenic shear wave elastography beyond portal hypertension: a narrative review of non-portal applications.. doi.org. https://doi.org/10.15557/jou.2026.0020

What does the evidence say?

The retrieved papers provide strong clinical and epidemiological evidence that both schistosomiasis (specifically S. mansoni) and malaria are major contributors to hepatosplenomegaly, liver fibrosis, and portal vein dilation in endemic regions.

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