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Embryonic stem cells are derived from the inner cell mass of a blastocyst.
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SUPPORTED
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10 sources for · 0 against
Is it true that embryonic stem cells are derived from the inner cell mass of a blastocyst?
Yes. A reference article states directly that embryonic stem cells are pluripotent stem cells derived from the inner cell mass of a blastocyst, and a review article likewise says ESCs are mostly derived from the ICM of blastocyst-stage embryos. Several species-specific studies (feline, porcine, bovine, mouse, human) independently report deriving ESCs from the inner cell mass of blastocysts.
Verdict: SUPPORTED · 10 sources for, 0 against · Last checked
Evidence for · 10
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Embryonic stem cell. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Embryonic_stem_cell
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More for · 9
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Yoshida, T., Tsukamoto, M., Kimura, K., Tanaka, M., Kuwamura, M., & Hatoya, S. (2025). Establishment of feline embryonic stem cells from the inner cell mass of blastocysts produced in vitro. doi.org. https://doi.org/10.1016/j.reth.2024.11.010
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Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1007/s00018-018-2965-y
Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm
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Stevens, A., Smith, H., Garner, T., Minogue, B., Sneddon, S. F., Shaw, L., Keramari, M., Oldershaw, R. A., Bates, N., Brison, D., & Kimber, S. (2018). Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm. doi.org. https://doi.org/10.1101/411439
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Telugu, B. P., Ezashi, T., Alexenko, A., Lee, S., Prather, R. S., & Roberts, R. M. (2011). 216 EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLS ANALOGOUS TO INNER CELL MASS-DERIVED LIF-DEPENDENT MOUSE EMBRYONIC STEM CELLS ESTABLISHED FROM THE DOMESTIC PIG, SUS SCROFA. doi.org. https://doi.org/10.1071/rdv24n1ab216
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iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells. (2013). hal.science. https://doi.org/10.1016/j.jprot.2013.03.015
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Desrochers, L. M., Bordeleau, F., Reinhart-King, C. A., Cerione, R. A., & Antonyak, M. (2016). Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation. doi.org. https://doi.org/10.1038/ncomms11958
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Strawbridge, S., Schrattel, A. K., Humphreys, P., Jones, K. A., Artus, J., Hadjantonakis, A., Fletcher, A. G., & Nichols, J. (2025). Donor embryonic stem cells displace host cells of 8-cell-stage chimeras to the extra-embryonic lineages by spatial crowding and FGF4 signalling. doi.org. https://doi.org/10.1242/dev.204518
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Dvash, T., Lavon, N., & Fan, G. (2010). Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells.. doi.org. https://doi.org/10.1371/journal.pone.0011330
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Changes in H3K4me3 and H3K27me3 landscapes during in vitro derivation of embryonic stem cells -a bovine study. (2024). hal.inrae.fr. https://hal.inrae.fr/hal-05219450v1
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