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Elevated LDL cholesterol is causally linked to coronary heart disease.
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SUPPORTED
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10 sources for · 0 against
Is it true that elevated LDL cholesterol is causally linked to coronary heart disease?
Yes. A Mendelian randomization study reports a causal risk ratio of 1.8 for ischemic heart disease per 1 mmol/L higher LDL cholesterol, and a review states elevated LDL-C is a necessary condition for atherogenesis, validated by cohorts and randomized trials. Other cohort and reference items report consistent associations between elevated LDL cholesterol and coronary heart disease.
Verdict: SUPPORTED · 10 sources for, 0 against · Last checked
Evidence for · 10
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Coronary artery disease. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Coronary_artery_disease
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More for · 9
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Calnan, M. (2002). Preventing Coronary Heart Disease. play.google.com. https://play.google.com/store/books/details?id=ip6KAgAAQBAJ&source=gbs_api
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Goldbourt, U., Faire, U. d., & Berg, K. (2012). Genetic factors in coronary heart disease. play.google.com. https://play.google.com/store/books/details?id=V-StBAAAQBAJ&source=gbs_api
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Tamilmani, K., Yogeswari, V., & Shanthi, K. M. (2023). Non HDL Cholesterol as a Better Predictor of Coronary Heart Disease Risk in Obesity. zenodo.org. https://doi.org/10.5281/zenodo.12819380
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Ueda, P., Gulayin, P., & Danaei, G. (2018). Long-term moderately elevated LDL-cholesterol and blood pressure and risk of coronary heart disease. doi.org. https://doi.org/10.1371/journal.pone.0200017
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Xiao, J., Chen, L., Ye, W., & Huang, W. (2023). Differential age-specific effects of LDL cholesterol and body mass index on the risk of coronary heart disease. doi.org. https://doi.org/10.1101/2023.02.21.23286273
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Abdi, A., Hasheminia, M., Hadaegh, P., Tohidi, M., Azizi, F., & Hadaegh, F. (2025). Remnant cholesterol and risk of coronary heart disease beyond LDL-cholesterol and HDL-cholesterol: a population-based prospective cohort study. doi.org. https://doi.org/10.1093/eurheartj/ehaf784.3688
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Elevated Remnant Cholesterol Causes Both Low-Grade Inflammation and Ischemic Heart Disease, Whereas Elevated Low-Density Lipoprotein Cholesterol Causes Ischemic Heart Disease Without Inflammation. (n.d.). cir.nii.ac.jp. https://doi.org/10.1161/circulationaha.113.003008
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Serum Cholesterol Levels and Risk of Cardiovascular Death: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.3390/ijerph19148272
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ME, M., MD, S., & PP, T. (2022). There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness.. doi.org. https://doi.org/10.1016/j.ajpc.2022.100371
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