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the claim

DNA methylation patterns can be inherited across generations.

the verdict
INSUFFICIENT LEANING
Recorded sources
7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that DNA methylation patterns can be inherited across generations?

Unclear. Several peer-reviewed and reference sources report that DNA methylation patterns can be transmitted across generations, but each covers only a specific organism, gene, or context (plants, honey bees, rodents, trauma cohorts), and some describe the general mechanism as still debated in mammals. No single source establishes the general claim outright.

Verdict: PARTIAL LEAN · 7 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 7
2020
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The (not so) Controversial Role of DNA Methylation in Epigenetic Inheritance Across Generations. (2020). doi.org. https://doi.org/10.1007/978-3-030-35213-4_10

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More for · 6
2014
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Patterns of DNA Methylation in Animals: An Ecotoxicological Perspective. (2014). doi.org. https://doi.org/10.1093/icb/icu025

2021
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Yagound, B., Remnant, E., Buchmann, G., & Oldroyd, B. (2021). Reply to Soley: DNA methylation marks are stably transferred across generations in honey bees. doi.org. https://doi.org/10.1073/pnas.2109211118

2026
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O, F., K, C., D, J., & A, K. (2026). When Trauma Crosses Generations: Mechanisms, Clinical Patterns and Therapeutic Implications of Transgenerational Trauma-A Systematic Review.. doi.org. https://doi.org/10.3390/cells15070609

2017
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Hofmeister, B. T., Lee, K., Rohr, N. A., Hall, D. W., & Schmitz, R. J. (2017). Stable inheritance of DNA methylation allows creation of epigenotype maps and the study of epiallele inheritance patterns in the absence of genetic variation. doi.org. https://doi.org/10.1186/s13059-017-1288-x

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encyclopedia-of-science-technology-10e-all. (n.d.). archive.org. https://archive.org/details/encyclopedia-of-science-technology-10e-all

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Transgenerational epigenetic inheritance - Wikipedia. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Transgenerational_epigenetic_inheritance

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held for human review18 Oct 2026
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