Cyclophosphamide use is associated with reproductive system disorders including infertility, ovarian failure, and azoospermia.
Is it true that Cyclophosphamide use is associated with reproductive system disorders including infertility, ovarian failure, and azoospermia?
Yes. Cyclophosphamide treatment is well-established to induce reproductive toxicity, frequently resulting in ovarian failure, diminished ovarian reserve, impaired spermatogenesis, and long-term infertility.
Verdict: SUPPORTED · 6 sources for, 0 against · Last checked
The retrieved literature consistently confirms that cyclophosphamide is a gonadotoxic chemotherapeutic agent used to model and induce reproductive disorders such as premature ovarian failure and impaired spermatogenesis in experimental and clinical contexts.
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MM, A., B, A., K, A., A, A., & IM, S. (2026). Exosomes in oncofertility: emerging roles in chemotherapy-induced reproductive damage and fertility preservation.. doi.org. https://doi.org/10.1530/raf-25-0149
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Z, M., F, P., L, D., Z, L., & X, H. (2026). [A dataset of metabolites and potential mechanisms of chemotherapy-induced premature ovarian failure based on non-targeted metabolomics].. doi.org. https://doi.org/10.13345/j.cjb.260131
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L, N., Z, W., X, H., Y, Y., J, L., H, Z., & D, X. (2026). Astaxanthin attenuates CTX-induced premature ovarian failure by alleviating ovarian apoptosis and autophagy in vivo.. doi.org. https://doi.org/10.1186/s13048-026-02175-x
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J, Z., Y, L., B, Z., S, W., Y, L., H, H., X, Z., & C, L. (2026). Gut Microbiota-Derived Short-Chain Fatty Acids Driven by N-Carbamylglutamate Alleviates Premature Ovarian Failure Through Suppressing Ferroptosis.. doi.org. https://doi.org/10.1096/fj.202504547rrr
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M, A., MS, Ü., F, A., E, Ö., & S, T. (2026). Therapeutic Effects of Stromal Stem Cells Derived from Ovarian Tissue in a Cyclophosphamide-Induced Rat Model of Ovarian Failure.. doi.org. https://doi.org/10.1007/s43032-026-02114-7
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S, L., T, C., H, C., B, G., & C, Z. (2026). The impact of animal models on translating male infertility research from bench to bedside: a narrative review.. doi.org. https://doi.org/10.1186/s12958-026-01607-z
What does the evidence say?
The retrieved literature consistently confirms that cyclophosphamide is a gonadotoxic chemotherapeutic agent used to model and induce reproductive disorders such as premature ovarian failure and impaired spermatogenesis in experimental and clinical contexts.
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