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the claim

Clostridium tetani bacteria cause disease by excreting a neurotoxin that travels to the nervous system.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Clostridium tetani bacteria cause disease by excreting a neurotoxin that travels to the nervous system?

Yes. Clostridium tetani bacteria cause disease by releasing a potent neurotoxin that travels via retrograde axonal transport into the nervous system.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

Multiple high-quality studies and reviews (such as papers 0, 3, 4, and 11) confirm that Clostridium tetani produces a neurotoxin that enters nerve cells and travels to the central nervous system to cause tetanus.

Evidence for · 4
Selective retrograde transsynaptic transfer of a protein, tetanus toxin, subsequent to its retrograde axonal transport
1979
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Schwab, M., Suda, K., & Thoenen, H. (1979). Selective retrograde transsynaptic transfer of a protein, tetanus toxin, subsequent to its retrograde axonal transport. doi.org. https://doi.org/10.1083/jcb.82.3.798

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More for · 3
Tetanus: recognition and management.
2025
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R, S., AR, S., DR, R., S, d. S., G, G., C, W., HTH, D., CL, T., AR, M., & C, C. (2025). Tetanus: recognition and management.. doi.org. https://doi.org/10.1016/s1473-3099(25)00292-0

Regulatory Networks Controlling Neurotoxin Synthesis in Clostridium botulinum and Clostridium tetani
2022
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Popoff, M. R. & Brüggemann, H. (2022). Regulatory Networks Controlling Neurotoxin Synthesis in Clostridium botulinum and Clostridium tetani. doi.org. https://doi.org/10.3390/toxins14060364

Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.
2026
Get citation
MR, P. (2026). Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.. doi.org. https://doi.org/10.3390/toxins18010035

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