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the claim
Certain pharmaceutical drugs undergo racemization or stereoconversion in vivo
the verdict
SUPPORTED
the evidence backs this
confidence 90/100

Certain pharmaceutical drugs undergo racemization or stereoconversion in vivo, as demonstrated by studies on agents like thalidomide and ibuprofen that invert between their enantiomeric forms.

Evidence for · 3
Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide
1995 · cited by 209
Demonstrates the rapid chiral inversion of thalidomide enantiomers in human blood and in vivo.
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More for · 2
Hydrogen/Deuterium Exchange for Chiral Stability Assessment in Acidic Methine-Containing Compounds.
2025 · cited by 2
Discusses racemization driven by keto-enol tautomerization in acidic methine-containing drugs such as glutarimide derivatives and thiazolidinediones.
Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats.
2017 · cited by 0
Shows that the inactive R-enantiomer of ibuprofen undergoes unidirectional chiral inversion to the active S-enantiomer in vivo.
The paper trail · every fact has a biography
first checked02 Aug 2026
judged → SUPPORTED · 9002 Aug 2026
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