Certain peptides are produced independently of ribosomes and non-ribosomal peptide synthase complexes
the verdict
SUPPORTED
the evidence backs this
confidence 85/100
Certain peptides are indeed synthesized through mechanisms that bypass both ribosomes and traditional non-ribosomal peptide synthase complexes, utilizing alternative pathways such as NRPS-independent synthetases.
Evidence for · 3
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature
2022 · cited by 41
Discusses ribosome-independent peptide synthetases and highlights the broader category of non-ribosomal peptide biosynthesis.
See more details
More for · 2
Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways
2023 · cited by 2
Details the biosynthesis of acyl-desferrioxamines via NRPS-independent (NIS) pathways.
Distal peptide elongation by a protease-like ligase and two distinct carrier proteins.
2026 · cited by 1
Demonstrates non-canonical peptide elongation pathways that operate independently of classical non-ribosomal peptide synthetases and ribosomes.