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the claim

Carbamazepine may exert negative chronotropic and dromotropic effects on the cardiac conduction system.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Carbamazepine may exert negative chronotropic and dromotropic effects on the cardiac conduction system?

Yes. Clinical evidence and case reports indicate that carbamazepine can cause negative chronotropic and dromotropic effects on the heart, leading to sinus node depression and atrioventricular conduction delays.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

Evidence for · 2
Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system.
1991
Study demonstrates that carbamazepine depresses sinus node function and causes atrioventricular conduction delay, confirming negative chronotropic and dromotropic effects.
Get citation
G, K., L, B., H, V., T, T., & O, E. (1991). Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system.. doi.org. https://doi.org/10.1016/0002-8703(91)90148-b

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More for · 1
Carbamazepine induced atrial tachycardia with complete AV block.
2014
Case report highlights that carbamazepine can cause conduction system issues such as sinus/nodal bradycardia and AV block, reinforcing its negative chronotropic and dromotropic impacts.
Get citation
K, K., A, Z., M, P., & K, P. (2014). Carbamazepine induced atrial tachycardia with complete AV block.. europepmc.org. https://europepmc.org/article/MED/25336888

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