Calcium signaling is essential for muscle contraction and fertilization.
Is it true that calcium signaling is essential for muscle contraction and fertilization?
Yes. Extensive physiological and cellular evidence establishes that calcium signaling plays a vital, non-negotiable role in mediating both muscle contraction and fertilization across species.
Verdict: SUPPORTED · 7 sources for, 0 against · Last checked
The claim is specific, testable, and directly addressed by multiple provided papers spanning muscle physiology and reproductive biology. All relevant literature overwhelmingly supports the fundamental role of calcium in both excitation-contraction coupling and fertilization/egg activation. Therefore, the verdict is SUPPORTED.
Get citation
Zotin, A. I. (1958). The Mechanism of Hardening of the Salmonid Egg Membrane after Fertilization or Spontaneous Activation. doi.org. https://doi.org/10.1242/dev.6.4.546
See more details
Get citation
A, K., N, O., T, W., T, N., Y, K., M, O., Y, Y., T, F., A, O., R, F., N, K., & J, I. (2025). The oocyte zinc transporter <i>Slc39a10/Zip10</i> is a regulator of zinc sparks during fertilization in mice.. doi.org. https://doi.org/10.7554/elife.106616
Get citation
Baylor, S. M. (2015). CalDyx: An interactive self-study teaching program on calcium dynamics during excitation-contraction coupling in skeletal muscle cells. doi.org. https://doi.org/10.1126/scisignal.2005839
Get citation
G, N., AP, N., DU, O., MV, O., DC, I., A, N., MJ, A., M, W., OC, O., AA, F., ED, E., AU, I., EJ, A., A, J., AH, U., DW, H., AI, A., & O, O. (2026). Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.. doi.org. https://doi.org/10.1080/19336950.2026.2724674
Get citation
C, Z., J, L., J, X., Q, L., Y, Z., X, Y., & J, G. (2026). Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure.. doi.org. https://doi.org/10.3389/fcvm.2026.1938059
Get citation
C, C., Y, M., D, J., & H, L. (2026). Modulation of satellite cell function to alleviate age-related sarcopenia: Electrical stimulation & Ca²⁺ signaling combined approach.. doi.org. https://doi.org/10.1016/j.isci.2026.116296
Get citation
Z, C., R, Q., C, Z., M, P., W, M., & Q, C. (2026). How Ocean Acidification Makes Marine Fish Reproduction Vulnerable: Physiological Mechanisms and Ecosystem Consequences.. doi.org. https://doi.org/10.3390/toxics14090834
What does the evidence say?
The claim is specific, testable, and directly addressed by multiple provided papers spanning muscle physiology and reproductive biology. All relevant literature overwhelmingly supports the fundamental role of calcium in both excitation-contraction coupling and fertilization/egg activation. Therefore, the verdict is SUPPORTED.
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work