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Calcium and vitamin D supplementation may reduce the risk of colorectal neoplasms by acting on normal mucosa to prevent early-stage colorectal carcinogenesis.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that calcium and vitamin D supplementation may reduce the risk of colorectal neoplasms by acting on normal mucosa to prevent early-stage colorectal carcinogenesis?

Yes. Calcium and vitamin D supplementation is supported by clinical and molecular evidence to help prevent early-stage colorectal carcinogenesis by acting on normal colorectal mucosa.

Verdict: SUPPORTED · 3 sources for, 1 against · Last checked

Evidence for · 3
Effects of supplemental calcium and vitamin D on the APC/β‐catenin pathway in the normal colorectal mucosa of colorectal adenoma patients
2016
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Liu, S., Barry, E. L., Baron, J. A., Rutherford, R. E., Seabrook, M. E., & Bostick, R. M. (2016). Effects of supplemental calcium and vitamin D on the APC/β‐catenin pathway in the normal colorectal mucosa of colorectal adenoma patients. doi.org. https://doi.org/10.1002/mc.22504

Evidence against · 1
Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial
2015
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Yang, B., Gross, M. D., Fedirko, V., McCullough, M. L., & Bostick, R. M. (2015). Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial. doi.org. https://doi.org/10.1158/1940-6207.capr-15-0168

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More for · 2
Integrative oncology in colorectal cancer: evidence-based strategies from prevention through survivorship.
2026
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C, S., R, L., F, B., Y, Z., T, X., & Z, H. (2026). Integrative oncology in colorectal cancer: evidence-based strategies from prevention through survivorship.. doi.org. https://doi.org/10.3389/fonc.2026.1860619

Understanding the Rising Incidence of Early-Onset Colorectal Cancer: Life-Course Determinants and Opportunities for Primary Prevention.
2026
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A, A., L, C., IE, F., M, S., & JM, M. (2026). Understanding the Rising Incidence of Early-Onset Colorectal Cancer: Life-Course Determinants and Opportunities for Primary Prevention.. doi.org. https://doi.org/10.3390/cancers18172852

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