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Axolotls regenerate their limbs.

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SUPPORTED
the evidence backs this
Recorded sources
10 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Axolotls regenerate their limbs?

Yes. Multiple peer-reviewed sources state directly that axolotls regenerate entire limbs after amputation, and several others treat this regenerative ability as established background. The claim is well supported.

Verdict: SUPPORTED · 10 sources for, 0 against · Last checked

Evidence for · 10
Cyclopamine induces digit loss in regenerating axolotl limbs
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Cyclopamine induces digit loss in regenerating axolotl limbs. (n.d.). cir.nii.ac.jp. https://doi.org/10.1002/jez.10110

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More for · 9
Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls
2020
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Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls. (2020). elifesciences.org. https://doi.org/10.7554/eLife.48511

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
2020
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Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting. (2020). doi.org. https://doi.org/10.3791/60156-v

CRISPR and its potential application to Limb Regeneration : A Literature Review
2024
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CRISPR and its potential application to Limb Regeneration : A Literature Review. (2024). hal.science. https://hal.science/hal-04734057v1

Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls
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Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls. (n.d.). nature.com. https://www.nature.com/articles/s41536-017-0034-z.pdf

Regrow like an axolotl
2017
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Regrow like an axolotl. (2017). doi.org. https://doi.org/10.1126/science.355.6325.592-a

Applying a Knock-In Strategy to Create Reporter-Tagged Knockout Alleles in Axolotls
2022
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Applying a Knock-In Strategy to Create Reporter-Tagged Knockout Alleles in Axolotls. (2022). doi.org. https://doi.org/10.1007/978-1-0716-2659-7_23

De novo transcriptome sequencing of axolotl blastema for identification of differentially expressed genes during limb regeneration.
2013
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Cheng-Han, W., Mong-Hsun, T., Chia-Chuan, H., Chien-Yu, C., & Hsuan-Shu, L. (2013). De novo transcriptome sequencing of axolotl blastema for identification of differentially expressed genes during limb regeneration.. archive.org. https://archive.org/details/pubmed-PMC3702472

Modeling proximalisation in axolotl limb regeneration
2025
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Arce, H., Ceccarelli, A. S., Córdoba, R. C., Oliveira, A. C. R., Yun, M. H., & Chara, O. (2025). Modeling proximalisation in axolotl limb regeneration. doi.org. https://doi.org/10.1038/s41598-025-10527-8

Lmx-1b and Wnt-7a expression in axolotl limb during development and regeneration
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Lmx-1b and Wnt-7a expression in axolotl limb during development and regeneration. (n.d.). cir.nii.ac.jp. https://doi.org/10.2535/ofaj.89.119

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