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the claim
Axo-axonic synapses exist on neuron terminals in the mammalian brain similarly to Aplysia
the verdict
SUPPORTED
the evidence backs this
confidence 80/100

Axo-axonic synapses are well-documented on neuron terminals and axon initial segments in the mammalian brain, functioning analogously to presynaptic regulatory mechanisms found in invertebrates like Aplysia.

Evidence for · 3
Triadic percolation induces dynamical topological patterns in higher-order networks.
2024 · cited by 6
Paper 0 notes that interneuron axo-axonic synapses enable presynaptic inhibition and facilitation in the brain.
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More for · 2
Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network.
2024 · cited by 2
Paper 3 details how cortical projection neuron axon initial segments receive GABAergic axo-axonic synaptic inputs from chandelier cells.
Theory of axo-axonic inhibition
2024 · cited by 0
Paper 8 discusses chandelier cells forming axo-axonic synapses on the initial segment of pyramidal cells in the cortex and hippocampus.
The paper trail · every fact has a biography
first checked01 Aug 2026
judged → SUPPORTED · 8001 Aug 2026
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