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the claim

Autism is associated with an elevated risk of schizophrenia.

the verdict
INSUFFICIENT LEANING
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that autism is associated with an elevated risk of schizophrenia?

Unclear. Several peer-reviewed items report shared genetic risk factors and pathways between autism spectrum disorder and schizophrenia, including a significant genetic correlation and overlapping risk genes. None directly measures whether autism itself is associated with elevated risk of schizophrenia, so the evidence covers only a related biological overlap.

Verdict: PARTIAL LEAN · 5 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 5
Modeling the maternal infection risk factor for schizophrenia and autism in mice
2012
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H., P. P. (2012). Modeling the maternal infection risk factor for schizophrenia and autism in mice. authors.library.caltech.edu. https://authors.library.caltech.edu/records/s9akh-f0469

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More for · 4
Autism spectrum disorder and schizophrenia: an updated conceptual review -
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Autism spectrum disorder and schizophrenia: an updated conceptual review - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1002/aur.2659

Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons
2023
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Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons. (2023). doi.org. https://doi.org/10.1523/jneurosci.0247-23.2023

Urinary metabolomic profiling in 22q11.2 deletion syndrome reveals microbial and mitochondrial signatures related to autism and psychosis risk
2025
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Minami, T., Ikegame, T., Tanaka, M., Kumagai, E., Kanehara, A., & Morishima, R. (2025). Urinary metabolomic profiling in 22q11.2 deletion syndrome reveals microbial and mitochondrial signatures related to autism and psychosis risk. doi.org. https://doi.org/10.1002/pcn5.70261

Joint analysis of de novo mutations from autism spectrum disorder, schizophrenia, congenital heart disease, and other developmental disorders improves detection power and implicates shared molecular pathways and CNS processes
2025
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Joint analysis of de novo mutations from autism spectrum disorder, schizophrenia, congenital heart disease, and other developmental disorders improves detection power and implicates shared molecular pathways and CNS processes. (2025). doi.org. https://doi.org/10.1093/nargab/lqaf162

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