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the claim

Antigen presentation by Ia molecules is required for T-cell recognition of the antigen and subsequent T-cell activation.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that antigen presentation by Ia molecules is required for T-cell recognition of the antigen and subsequent T-cell activation?

Yes. Experimental evidence confirms that antigen presentation via Ia (MHC class II) molecules is essential for T-cell recognition and subsequent activation.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

Evidence for · 2
Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal.
1981
Demonstrates that Ia+ antigen-presenting cells are required to generate the appropriate Ia-restricted antigen signal necessary for T-cell proliferation.
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Germain, R. N. (1981). Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal.. doi.org. https://doi.org/10.4049/jimmunol.127.5.1964

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More for · 1
Efficiency of antigen presentation to T cell clones by (B cell × B cell lymphoma) hybridomas correlates quantitatively with cell surface Ia antigen expression
1984
Shows that the efficiency of antigen presentation to T-cell clones directly correlates with cell surface Ia molecule expression.
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Bekkhoucha, F., Naquet, P., Pierres, A., Marchetto, S., & Pierres, M. (1984). Efficiency of antigen presentation to T cell clones by (B cell × B cell lymphoma) hybridomas correlates quantitatively with cell surface Ia antigen expression. doi.org. https://doi.org/10.1002/eji.1830140908

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