Antibodies to deamidated sequences of gliadin and to the autoantigen transglutaminase 2 are highly specific and sensitive serologic markers of celiac disease.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that antibodies to deamidated sequences of gliadin and to the autoantigen transglutaminase 2 are highly specific and sensitive serologic markers of celiac disease?

Yes. Antibodies targeting transglutaminase 2 and deamidated gliadin peptides are well-established, highly sensitive, and specific serological markers utilized in the clinical diagnosis of celiac disease.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked 4 Oct 2026

The analysis

The retrieved literature consistently supports the assertion that anti-transglutaminase 2 and anti-deamidated gliadin peptide antibodies are highly specific and sensitive biomarkers for celiac disease, with multiple studies and meta-analyses highlighting their diagnostic accuracy.

Evidence for · 4

Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis

2021

Demonstrates high sensitivity and specificity for anti-deamidated gliadin peptide IgG and anti-transglutaminase IgA in diagnosing celiac disease.

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Catassi, G. N., Pulvirenti, A., Monachesi, C., Catassi, C., & Lionetti, E. (2021). Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis. doi.org. https://doi.org/10.3390/nu14010007

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More for · 3

Antibodies Are Predictive for Diagnosis of Celiac Disease in Pediatric Type 1 Diabetes.

2025

Indicates that incorporating antibodies against deamidated gliadin peptides alongside transglutaminase markers enhances diagnostic precision.

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NZ, M., IM, M., A, K., ZZ, B., B, R., MA, B., C, B., & C, S. (2025). Antibodies Are Predictive for Diagnosis of Celiac Disease in Pediatric Type 1 Diabetes.. doi.org. https://doi.org/10.1210/clinem/dgaf146

A Review of the Methods Available for the Detection of Antibodies Against Transglutaminase and Deaminated Gliadin in Celiac Disease, Traditional and Emerging Technologies.

2026

Confirms that anti-transglutaminase and deamidated gliadin antibodies serve as the reliable diagnostic cornerstone and sensitive serological markers for celiac disease.

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D, L. & GD, K. (2026). A Review of the Methods Available for the Detection of Antibodies Against Transglutaminase and Deaminated Gliadin in Celiac Disease, Traditional and Emerging Technologies.. europepmc.org. https://europepmc.org/article/MED/42707802

Prevalence of celiac disease in a Tunisian cohort.

2025

Shows 100% specificity and sensitivity for both tTG IgA and DGP autoantibodies across a cohort, reinforcing their strong diagnostic utility.

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M, G., M, K., T, S., S, M., F, M., S, R., ZB, C., & I, G. (2025). Prevalence of celiac disease in a Tunisian cohort.. doi.org. https://doi.org/10.3389/fgstr.2025.1619533

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