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the claim

Anti-Müllerian hormone concentration is not dependent on the menstrual cycle.

the verdict
CONTESTED
contested - evenly split
Recorded sources
2 sources for · 2 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Anti-Müllerian hormone concentration is not dependent on the menstrual cycle?

Partly. Whether anti-Müllerian hormone (AMH) concentration remains stable throughout the menstrual cycle is contested, with some studies reporting no significant fluctuation and others documenting statistically significant intra- or inter-cycle variations.

Verdict: CONTESTED · 2 sources for, 2 against · Last checked

The analysis

The retrieved literature contains conflicting evidence regarding AMH stability across the menstrual cycle. While earlier and some cross-sectional data suggest serum AMH levels do not vary significantly or remain stable enough not to require cycle-timed measurements, more recent prospective cohorts and larger studies indicate statistically significant biological variability across cycles. Given these conflicting findings in the literature, the claim is best classified as contested.

The evidence we hold leans evenly split

How this was weighed

official record 3x · fact-check 2x · hedged 1x · crowd & reference 1x

  • Serum anti-Mullerian hormone throughout the human menstrual · peer-reviewed · supports · weight 2 · 2006
  • Age and Follicle-Stimulating Hormone as Variables Independen · peer-reviewed · supports · weight 1 · 2026
  • Biological variability in serum anti-Müllerian hormone throu · peer-reviewed · refutes · weight 1.6 · 2014
  • Inter-cycle variability of anti-Müllerian hormone: implicati · peer-reviewed · refutes · weight 1.05 · 2024
Evidence for · 2
Serum anti-Mullerian hormone throughout the human menstrual cycle.
2006
This longitudinal study found no significant changes in serum AMH levels throughout the menstrual cycle.
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Marca, A. L., Stabile, G., Artenisio, A., & Volpe, A. (2006). Serum anti-Mullerian hormone throughout the human menstrual cycle.. doi.org. https://doi.org/10.1093/HUMREP/DEL291

Evidence against · 2
Biological variability in serum anti-Müllerian hormone throughout the menstrual cycle in ovulatory and sporadic anovulatory cycles in eumenorrheic women.
2014
This prospective cohort study demonstrated that serum AMH levels vary statistically significantly across both ovulatory and sporadic anovulatory menstrual cycles.
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Kissell, K., Danaher, M., Schisterman, E., Wactawski-Wende, J., Ahrens, K. A., Schliep, K., Perkins, N., Sjaarda, L., Weck, J., & Mumford, S. (2014). Biological variability in serum anti-Müllerian hormone throughout the menstrual cycle in ovulatory and sporadic anovulatory cycles in eumenorrheic women.. doi.org. https://doi.org/10.1093/humrep/deu142

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More for · 1
Age and Follicle-Stimulating Hormone as Variables Independently Associated with Serum Anti-Müllerian Hormone in Women Attending a Tertiary Gynaecology Clinic: A Retrospective Cross-Sectional Study Using Censoring-Aware Modelling.
2026
This cross-sectional study found that routine reproductive hormones like LH, estradiol, and progesterone showed no independent associations with AMH when sampling was not standardized to the cycle.
Get citation
MH, K., B, D., A, P., T, E., SK, S., & AG, Y. (2026). Age and Follicle-Stimulating Hormone as Variables Independently Associated with Serum Anti-Müllerian Hormone in Women Attending a Tertiary Gynaecology Clinic: A Retrospective Cross-Sectional Study Using Censoring-Aware Modelling.. doi.org. https://doi.org/10.3390/metabo16090610

More against · 1
Inter-cycle variability of anti-Müllerian hormone: implications for predicting controlled ovarian stimulation cycle outcomes
2024
This study found significant cycle-to-cycle variation in serum AMH levels measured in consecutive early follicular phases.
Get citation
Şükür, Y., Aslan, B., Kaplan, N. B., Doğru, M., Özmen, B., Sönmezer, M., Berker, B., Atabekoğlu, C., & Aytaç, R. (2024). Inter-cycle variability of anti-Müllerian hormone: implications for predicting controlled ovarian stimulation cycle outcomes. doi.org. https://doi.org/10.1186/s13048-024-01517-x

What does the evidence say?

The retrieved literature contains conflicting evidence regarding AMH stability across the menstrual cycle. While earlier and some cross-sectional data suggest serum AMH levels do not vary significantly or remain stable enough not to require cycle-timed measurements, more recent prospective cohorts and larger studies indicate statistically significant biological variability across cycles. Given these conflicting findings in the literature, the claim is best classified as contested.

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