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the claim

Anthracycline treatment is associated with an increased risk of heart failure.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Anthracycline treatment is associated with an increased risk of heart failure?

Yes. Extensive clinical and experimental evidence demonstrates that anthracycline treatment is strongly associated with an increased risk of cardiotoxicity and subsequent heart failure.

Verdict: SUPPORTED · 7 sources for, 0 against · Last checked

The analysis

The retrieved literature unanimously and consistently supports the association between anthracyclines (such as doxorubicin) and an increased risk of cardiotoxicity, cardiomyopathy, and heart failure. Multiple reviews and experimental studies document this well-established clinical adverse effect.

Evidence for · 7
Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system—from molecular mechanisms to therapeutic applications
2020
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Sobczuk, P., Czerwińska, M., Kleibert, M., & Cudnoch-Jędrzejewska, A. (2020). Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system—from molecular mechanisms to therapeutic applications. doi.org. https://doi.org/10.1007/s10741-020-09977-1

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More for · 6
Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload.
2026
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C, G., D, P., I, J., V, B., A, A., C, P., A, d. M., L, C., D, M., C, C., GJ, L., J, V., J, O., V, F., J, S., & B, I. (2026). Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload.. doi.org. https://doi.org/10.1093/eurheartj/ehaf1060

Reassessing the Role of Anthracyclines in Early HER2-Positive Breast Cancer in the Era of HER2-Targeted Therapy and Treatment De-Escalation: A Systematic Review and Narrative Synthesis.
2026
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Z, M., N, A., AJ, H., R, I., & M, A. (2026). Reassessing the Role of Anthracyclines in Early HER2-Positive Breast Cancer in the Era of HER2-Targeted Therapy and Treatment De-Escalation: A Systematic Review and Narrative Synthesis.. doi.org. https://doi.org/10.3390/jcm15187303

Understanding the distinct role of PI3K(p110<i>α</i>) in cancer and the heart to prevent chemotherapy-induced cardiotoxicity: mechanisms and therapeutic opportunities.
2026
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TG, B., YK, T., AJ, E., & JR, M. (2026). Understanding the distinct role of PI3K(p110<i>α</i>) in cancer and the heart to prevent chemotherapy-induced cardiotoxicity: mechanisms and therapeutic opportunities.. doi.org. https://doi.org/10.3389/fcvm.2026.1891148

Anthracycline-Induced Cardiotoxicity: Causes, Mechanisms, and Prevention.
2020
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Bhagat, A. & Kleinerman, E. S. (2020). Anthracycline-Induced Cardiotoxicity: Causes, Mechanisms, and Prevention.. doi.org. https://doi.org/10.1007/978-3-030-43032-0_15

Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity.
2023
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Wu, L., Wang, L., Du, Y., Zhang, Y., & Ren, J. (2023). Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity.. doi.org. https://doi.org/10.1016/j.tips.2022.10.003

Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches.
2022
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Sheibani, M., Azizi, Y., Shayan, M., Nezamoleslami, S., Eslami, F., Farjoo, M. H., & Dehpour, A. R. (2022). Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches.. doi.org. https://doi.org/10.1007/s12012-022-09721-1

What does the evidence say?

The retrieved literature unanimously and consistently supports the association between anthracyclines (such as doxorubicin) and an increased risk of cardiotoxicity, cardiomyopathy, and heart failure. Multiple reviews and experimental studies document this well-established clinical adverse effect.

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