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the claim

Allogeneic hematopoietic stem-cell transplantation can exert a therapeutic graft-versus-malignancy effect through nonself immune effector cells contained in the donor stem cell preparation.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Allogeneic hematopoietic stem-cell transplantation can exert a therapeutic graft-versus-malignancy effect through nonself immune effector cells contained in the donor stem cell preparation?

Yes. Allogeneic hematopoietic stem-cell transplantation exerts a well-established graft-versus-malignancy effect mediated by donor immune cells attacking recipient tumor cells.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The claim is a specific, well-established scientific premise in transplant immunology. Multiple provided papers directly discuss or review the graft-versus-leukemia/myeloma effects mediated by donor lymphocytes and cellular therapies following allogeneic stem-cell transplantation, supporting the statement with no papers contradicting it.

Evidence for · 3
2002
Demonstrates that donor lymphocyte infusions can elicit graft-versus-leukemia effects through immune responses against host cells in transplanted models.
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Billiau, A. D., Fevery, S., Rutgeerts, O., Landuyt, W., & Waer, M. (2002). Crucial role of timing of donor lymphocyte infusion in generating dissociated graft-versus-host and graft-versus-leukemia responses in mice receiving allogeneic bone marrow transplants. doi.org. https://doi.org/10.1182/blood-2002-02-0419

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More for · 2
2024
Reviews how post-transplant cellular therapies utilizing donor immune cells aim to reduce relapse by targeting malignancies.
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P, V., P, K., Y, C., CH, J., CM, B., & SO, C. (2024). Adoptive cellular therapy after hematopoietic stem cell transplantation.. doi.org. https://doi.org/10.1002/ajh.27204

2021
Highlights the graft-versus-myeloma effect driven by donor lymphocyte infusions following allogeneic stem cell transplantation.
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Gagelmann, N. & Kröger, N. (2021). Donor Lymphocyte Infusion to Enhance the Graft-versus-Myeloma Effect. doi.org. https://doi.org/10.3390/hemato2020012

What does the evidence say?

The claim is a specific, well-established scientific premise in transplant immunology. Multiple provided papers directly discuss or review the graft-versus-leukemia/myeloma effects mediated by donor lymphocytes and cellular therapies following allogeneic stem-cell transplantation, supporting the statement with no papers contradicting it.

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