Allogeneic hematopoietic stem-cell transplantation can exert a therapeutic graft-versus-malignancy effect through nonself immune effector cells contained in the donor stem cell preparation.
Is it true that Allogeneic hematopoietic stem-cell transplantation can exert a therapeutic graft-versus-malignancy effect through nonself immune effector cells contained in the donor stem cell preparation?
Yes. Allogeneic hematopoietic stem-cell transplantation exerts a well-established graft-versus-malignancy effect mediated by donor immune cells attacking recipient tumor cells.
Verdict: SUPPORTED · 3 sources for, 0 against · Last checked
The claim is a specific, well-established scientific premise in transplant immunology. Multiple provided papers directly discuss or review the graft-versus-leukemia/myeloma effects mediated by donor lymphocytes and cellular therapies following allogeneic stem-cell transplantation, supporting the statement with no papers contradicting it.
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Billiau, A. D., Fevery, S., Rutgeerts, O., Landuyt, W., & Waer, M. (2002). Crucial role of timing of donor lymphocyte infusion in generating dissociated graft-versus-host and graft-versus-leukemia responses in mice receiving allogeneic bone marrow transplants. doi.org. https://doi.org/10.1182/blood-2002-02-0419
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P, V., P, K., Y, C., CH, J., CM, B., & SO, C. (2024). Adoptive cellular therapy after hematopoietic stem cell transplantation.. doi.org. https://doi.org/10.1002/ajh.27204
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Gagelmann, N. & Kröger, N. (2021). Donor Lymphocyte Infusion to Enhance the Graft-versus-Myeloma Effect. doi.org. https://doi.org/10.3390/hemato2020012
What does the evidence say?
The claim is a specific, well-established scientific premise in transplant immunology. Multiple provided papers directly discuss or review the graft-versus-leukemia/myeloma effects mediated by donor lymphocytes and cellular therapies following allogeneic stem-cell transplantation, supporting the statement with no papers contradicting it.
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