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Acetaminophen use causes kidney damage in adults.
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CONTESTED PARTIAL
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7 sources for · 1 against
Is it true that acetaminophen use causes kidney damage in adults?
Partly. Several reviews and animal studies indicate acetaminophen can cause kidney injury, particularly in overdose or toxicity settings, and one adult meta-analysis reports a suggested but unclear association with renal impairment. One rat study found no effect on progression of existing renal damage, so the evidence covers only part of the claim and is mixed.
Verdict: CONTESTED PARTIAL · 7 sources for, 1 against · Last checked
Evidence for · 7
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Şahin, S., Aydın, A., Göçmen, A. Y., & Kaymak, E. (2024). Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice. doi.org. https://doi.org/10.1007/s00210-023-02937-0
Evidence against · 1
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Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. (n.d.). cir.nii.ac.jp. https://doi.org/10.1016/j.lfs.2012.09.018
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More for · 6
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Kocamüftüoğlu, G. O., Tektemur, N. K., Güzel, E., Tektemur, A., & Ozan, I. E. (2024). Effects of Concomitant Use of N-acetylcysteine and Cyclosporine A on Acetaminophen-induced Acute Kidney Injury in Mice. doi.org. https://doi.org/10.18805/ijar.bf-1736
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Comparative Effect of Ginger (Zingiber officinale) Supplement on Hepato-renal Damages Induced by Acetaminophen Toxicity in Wistar Rats. (2021). hal.science. https://hal.science/hal-05310871v1
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Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.23876/j.krcp.19.106
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Klimov, L. Y., Aksenov, A. G., Popova, E. V., Pogorelova, L. V., Cucaev, R. O., & Bykov, Y. V. (2018). Acetaminophen-induced fulminant liver failure (clinical case presentation and a review of the literature). doi.org. https://doi.org/10.21518/2079-701x-2018-11-76-83
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Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms. (n.d.). cir.nii.ac.jp. https://doi.org/10.18053/jctres.03.201703.005
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Brune, K., Renner, B., & Tiegs, G. (2015). Acetaminophen/paracetamol: A history of errors, failures and false decisions.. doi.org. https://doi.org/10.1002/ejp.621
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