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the claim

A 2022 umbrella review in Molecular Psychiatry found no consistent evidence that depression is caused by low serotonin levels or activity.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that a 2022 umbrella review in Molecular Psychiatry found no consistent evidence that depression is caused by low serotonin levels or activity?

Yes. The 2022 Molecular Psychiatry umbrella review by Moncrieff and colleagues itself reports no consistent evidence that depression is caused by lowered serotonin activity or concentrations, and a reference page restates that finding. A 2023 commentary disputes the review's conclusion but does not deny that the review reached it.

Verdict: SUPPORTED · 2 sources for, 1 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 2
What Does Serotonin Do?
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What Does Serotonin Do?. (n.d.). simplypsychology.org. https://www.simplypsychology.org/what-is-serotonin.html

Evidence against · 1
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression -
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A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1038/s41380-023-02095-y

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More for · 1
The serotonin theory of depression: a systematic umbrella review of the evidence
2022
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Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: a systematic umbrella review of the evidence. doi.org. https://doi.org/10.1038/s41380-022-01661-0

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