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the claim
5-fluorouracil treatment can cause myocardiotoxicity in humans.
the verdict
SUPPORTED
the evidence backs this
Recorded sources
12 sources for · 0 against
Is it true that 5-fluorouracil treatment can cause myocardiotoxicity in humans?
Yes. Clinical literature and studies consistently demonstrate that 5-fluorouracil treatment can induce significant cardiotoxicity in humans, manifesting as coronary vasospasm, myocardial ischemia, arrhythmias, and acute heart failure.
Verdict: SUPPORTED · 12 sources for, 0 against · Last checked
The analysis
All provided papers consistently document the cardiotoxic effects of 5-fluorouracil (and its prodrug capecitabine) in humans and animal models, noting mechanisms such as coronary vasospasm, oxidative stress, and myocardial injury. There are no papers contradicting this established finding.
Evidence for · 12
Evaluates cardioprotective strategies against 5-fluorouracil-induced cardiac injury and oxidative stress in rat models.
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KM, A., MM, A., SS, E., YT, F., MA, M., AM, E., MM, M., SA, A., MT, A., BS, M., RA, H., AA, E., MHA, G., & NA, M. (2026). EGCG-mediated selenium nanoparticles protect against 5-fluorouracil-induced cardiotoxicity via Nrf2/Keap1 signaling.. doi.org. https://doi.org/10.1007/s00210-026-05413-7
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More for · 11
Discusses clinical challenges and successful management of fluoropyrimidine-induced coronary vasospasm.
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UV, M., K, D., E, K., A, C., S, R., J, S., D, M., C, H., I, P., & V, I. (2025). Rechallenging Patients With Fluoropyridine-Induced Coronary Vasospasm: 5 Success Stories.. doi.org. https://doi.org/10.1016/j.jaccas.2025.104750
Examines how chemoradiotherapy involving fluoropyrimidines induces acute and chronic cardiotoxic risks including ischemia and heart failure.
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C, K., H, S., K, J., M, A., B, S., & AK, Y. (2026). Cardiotoxicity of Chemoradiotherapy in Patients With Esophageal Cancer: A Systematic Review.. doi.org. https://doi.org/10.7759/cureus.100822
Investigates the incidence of clinical cardiotoxicity and myocardial ischemia during treatment with capecitabine, a 5-fluorouracil prodrug.
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A, D., M, S., KK, V., AS, S., SE, B., J, F., M, V., & DL, N. (2025). Incidence of myocardial ischemia during treatment with capecitabine: a cohort study with Holter recording and cardiac biomarkers.. doi.org. https://doi.org/10.2340/1651-226x.2025.43089
Analyzes the molecular mechanisms of 5-fluorouracil-induced cardiotoxicity and evaluates potential attenuation using antioxidants.
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G, I., C, C., Ö, K., TC, S., E, D., S, K., & FM, K. (2026). Multifactorial mechanisms of 5-fluorouracil-induced cardiotoxicity and the cardioprotective role of gallic acid.. doi.org. https://doi.org/10.1007/s11033-026-12716-8
Reports a clinical case of acute heart failure and cardiogenic shock associated with 5-fluorouracil exposure.
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Y, D., R, S., K, D., S, B., R, D., & M, M. (2026). 5-Fluorouracil (5-FU) Cardiotoxicity: A Stressful Event.. doi.org. https://doi.org/10.1155/cric/2215209
Reviews severe fluoropyrimidine-associated cardiotoxicity, noting manifestations from vasospasm to acute biventricular dysfunction and shock.
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S, F., MG, D. B., G, S., C, A., R, M., E, M., G, T., A, M., L, S., PM, S., F, B., & T, S. (2026). Fluoropyrimidine Cardiotoxicity: Role of Uridine Triacetate and Pharmacogenomic Insights from a Case of 5-FU-Induced Cardiogenic Shock.. doi.org. https://doi.org/10.1097/fjc.0000000000001853
Investigates green-synthesized nanoparticle treatments to mitigate 5-fluorouracil-induced myocardial injury and oxidative stress.
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SM, N., AM, G., SA, T., NH, H., MR, M., AG, B., MM, A., MM, A., KM, A., & MHA, G. (2026). Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles.. doi.org. https://doi.org/10.1038/s41598-026-69038-9
Classifies fluoropyrimidine toxicity by coronary vasomotor dysfunction and associated myocardial complications.
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P, S., A, K., K, Z., P, M., J, N., F, R., AA, S., F, G., A, K., & E, B. (2026). Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity.. doi.org. https://doi.org/10.1007/s12012-026-10191-y
Reports that 2.9% of patients receiving intravenous 5-fluorouracil developed chest pain and vasospasm mimicking acute coronary syndrome.
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K, K., K, H., B, S., & G, R. (2026). Effective management of 5-fluorouracil-induced coronary vasospasm allowing chemotherapy continuation: a single-center observational study.. doi.org. https://doi.org/10.1186/s40959-026-00526-7
Notes that cardiotoxicity associated with cancer therapy is a recognized cause of elevated serum cardiac troponin levels.
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K, B., B, M., & AÁ, M. (2026). Significance of Cardiac Troponin in Cancer Patients.. doi.org. https://doi.org/10.3390/cells15161435
Provides an overview of fluoropyrimidine-induced cardiotoxicity presenting as angina, arrhythmia, and other cardiac events.
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A, B., M, C., MHJ, A., C, S., A, R., R, A., Y, R., A, B., & NR, B. (2026). Navigating Cardiotoxicity in Cancer Treatment: Insights into Fluoropyrimidine-induced Cardiac Events.. doi.org. https://doi.org/10.2174/011573403x335593250413154832
What does the evidence say?
All provided papers consistently document the cardiotoxic effects of 5-fluorouracil (and its prodrug capecitabine) in humans and animal models, noting mechanisms such as coronary vasospasm, oxidative stress, and myocardial injury. There are no papers contradicting this established finding.
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