Tattooing is the procedure of implanting permanent pigment granules and additives into the dermal layer of the skin, serving various purposes such as decoration, medical identification, or accidental markings. There has been a significant rise in the popularity of decorative tattooing as a form of body art among both teenagers and young adults. Thus, the incidence of tattoos is increasing, with expanding applications such as permanent makeup, scar camouflage, nipple-areola, lips, and eyebrows tattooing, and utilization in oncological radiotherapy such as colon marking. However, there have been reported a broad range of adverse reactions linked to tattooing, encompassing allergic reactions, superficial and deep cutaneous infections, autoimmune disorders induced by the Koebner phenomenon, cutaneous tumors, and others. These reactions exhibit different onset times for symptoms, ranging from immediate manifestations after tattoo application to symptoms emerging several years later. Given the limited information on a tattoo's side effects, this review aims to elucidate the clinical spectrum of cutaneous complications of tattoos in different patients. The analysis will investigate both allergic and nonallergic clinical presentations of tattoo-related side effects, microscopic findings from skin biopsies, and therapeutic outcomes. This exploration is essential to improve our understanding of tattoo-related cutaneous complications and associated differential diagnoses and highlight the significance of patient awareness regarding potential risks before getting a tattoo.
The persistence of traditional tattoo inks presents an advantage for continuous and long‐term health monitoring in point of care devices. The replacement of tattoo pigments with optical biosensors aims a promising alternative for monitoring blood biomarkers. Tattoo inks functionalization enables the control of interstitial biomarkers with correlated concentrations in plasma, to diagnose diseases, evaluate progression, and prevent complications associated with physio pathological disorders or medication mismatches. The specific biomarkers in interstitial fluid provide a new source of information, especially for skin diseases. The study of tattoo inks displays insufficient regulation in their composition, a lack of reports of the related complications, and a need for further studies on their degradation kinetics. This review focuses on tattoo optical biosensors for monitoring dermal interstitial biomarkers and discusses the clinical advantages and main challenges for in vivo implantation.
Toxicological impact of photodegraded organic tattoo pigments on human cultured keratinocytes - Archive ouverte HAL × × × Loading...
× Communication Dans Un Congrès Année : 2023 Toxicological impact of photodegraded organic tattoo pigments on human cultured keratinocytes Lise Aubry (1) , Lucie Breuillé (1) , Thierry Douki (1) Afficher plus de détails 1 CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (17 rue des Martyrs 38054 Grenoble Cedex 9 - France) 1043177 SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé : DRF/IRIG/SYMMES (17, rue des Martyrs 38054 Grenoble cedex 09 - France) 1043175 INC-CNRS - Institut de Chimie - CNRS Chimie (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 3 rue Michel-Ange 75794 PARIS CEDEX 16 - France - France) 341038 CNRS - Centre National de la Recherche Scientifique : UMR5819 (France) 441569 IRIG - Institut de Recherche Interdisciplinaire de Grenoble : DRF/IRIG/DIESE (France) 555292 DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/IRIG (Direction de Recherche Fondamentale Fundamental Research Division CEA Saclay 91191 Gif-sur-Yvette - France) 465913 CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France) 300016 UGA - Université Grenoble Alpes (Adresse CS 40700 - 38058 Grenoble cedex - France) 1042703 Grenoble INP - Institut polytechnique de Grenoble - Grenoble Institute of Technology (46 avenue Félix Viallet 38031 Grenoble Cedex 1 - France) 1043329 UGA - Université Grenoble Alpes (Adresse CS 40700 - 38058 Grenoble cedex - France) 1042703 "> CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Lise Aubry Fonction : Auteur CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Lucie Breuillé Fonction : Auteur CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Thierry Douki Fonction : Auteur PersonId : 21328 IdHAL : thierry-douki ORCID : 0000-0002-5022-071X IdRef : 08571593X CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie CV Réduire la vue détaillée Résumé en Tattooing is very popular around the world.
In spite of the large population concerned, the safety of tattoos remains to be fully evaluated. A major issue is the pigments, which are insoluble compounds that persist in the skin dermis for years. Organic pigments, including azo and polycyclic pigments, are increasingly used in tattoo inks. Once in the dermis, these compounds may be altered by sun exposure or dermic macrophage activity. These processes may generate soluble molecules, which could diffuse into the epidermis and affect the major cells of this layer, keratinocytes. Interestingly, a link is suspected between tattooed skin and some cutaneous diseases like basal-cell carcinoma.
Only few articles deal with the toxicity of degraded pigments in the epidermis. This topic is the basis of ongoing work in our group. In vitro studies using the HaCaT keratinocytic cell line allowed us to unravel the effects of photodegradation on the toxicological profile (viability, oxidative stress) of a series of organic pigments. Ageing was simulated with a test chamber (Q-SUN Xe-1 Xenon) combining sunlight exposure and increased temperature (40°C). First, biological results show different cytotoxic profile between a series of pristine organic pigments and suspensions exposed to heat and simulated sunlight.
Domaines Sciences du Vivant [q-bio] Liste complète des métadonnées Connectez-vous pour contacter le contributeur https://hal.science/hal-04867986 Soumis le : lundi 13 janvier 2025-15:36:53 Dernière modification le : samedi 27 septembre 2025-19:39:37 Fichier non déposé Dates et versions hal-04867986 , version 1 (13-01-2025) Identifiants HAL Id : hal-04867986 , version 1 Citer Lise Aubry, Lucie Breuillé, Thierry Douki. Toxicological impact of photodegraded organic tattoo pigments on human cultured keratinocytes. 20th Congress of the European Society for Photobiology , Aug 2023, Lyon (FR), France.
TOXICOLOGICAL IMPACT OF PHOTODEGRADED ORGANIC TATTOO PIGMENTS ON HUMAN CULTURED KERATINOCYTES - Archive ouverte HAL × × × Loading...
× Communication Dans Un Congrès Année : 2023 TOXICOLOGICAL IMPACT OF PHOTODEGRADED ORGANIC TATTOO PIGMENTS ON HUMAN CULTURED KERATINOCYTES Lise Aubry (1) , Lucie Breuillé (1) , Thierry Douki (1) Afficher plus de détails 1 CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (17 rue des Martyrs 38054 Grenoble Cedex 9 - France) 1043177 SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé : DRF/IRIG/SYMMES (17, rue des Martyrs 38054 Grenoble cedex 09 - France) 1043175 INC-CNRS - Institut de Chimie - CNRS Chimie (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 3 rue Michel-Ange 75794 PARIS CEDEX 16 - France - France) 341038 CNRS - Centre National de la Recherche Scientifique : UMR5819 (France) 441569 IRIG - Institut de Recherche Interdisciplinaire de Grenoble : DRF/IRIG/DIESE (France) 555292 DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/IRIG (Direction de Recherche Fondamentale Fundamental Research Division CEA Saclay 91191 Gif-sur-Yvette - France) 465913 CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France) 300016 UGA - Université Grenoble Alpes (Adresse CS 40700 - 38058 Grenoble cedex - France) 1042703 Grenoble INP - Institut polytechnique de Grenoble - Grenoble Institute of Technology (46 avenue Félix Viallet 38031 Grenoble Cedex 1 - France) 1043329 UGA - Université Grenoble Alpes (Adresse CS 40700 - 38058 Grenoble cedex - France) 1042703 "> CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Lise Aubry Fonction : Auteur CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Lucie Breuillé Fonction : Auteur PersonId : 1486163 IdHAL : lucie-breuille ORCID : 0009-0001-1122-7142 CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Thierry Douki Fonction : Auteur CIBEST - Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie Réduire la vue détaillée Résumé en Tattooing is very popular around the world.
However, the safety of tattoo inks remains to be fully evaluated. These products contain pigments, which are insoluble compounds that persist in the skin dermis. Organic pigments including azo and polycyclic pigments are increasingly used for tattoos. These compounds may be altered by sun exposure or dermic macrophage activity. These processes may lead to generate soluble molecules, which could diffuse into the epidermis and affect the major cells of this layer, keratinocytes. Interestingly, a link is suspected between tattooed skin and some cutaneous diseases like basal-cell carcinoma. Only few articles deal with the toxicity of degraded pigments in epidermis.
This topic is the basis of ongoing work in our group. Methods: High-performance liquid chromatography coupled to mass spectrometry (HPLC-MS) is used to investigate the degradation of pigments. In vitro studies using the HaCat keratinocytic cell line allow us to unravel the effects of photodegradation and degradation by macrophages on the toxicological profile of pigments. Results: First results show different cytotoxic profile between a series of pristine organic pigments and suspensions exposed to heat and simulated sunlight. Analysis by HPLC-MS show that exposure of some pigments to ultraviolet light can generate photoproducts.
TOXICOLOGICAL IMPACT OF PHOTODEGRADED ORGANIC TATTOO PIGMENTS ON HUMAN CULTURED KERATINOCYTES. 6TH WORLD CONGRESS OF TATTOO & PIGMENT RESEARCH , May 2023, Vienne, Autriche, France. ⟨hal-04850915⟩ Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Collections CEA UGA CNRS INC-CNRS IRIG CEA-GRE SYMMES 42 Consultations 93 Téléchargements Partager More
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