Nuclear translation: What is the evidence? - PMC RNA . 2003 Jan;9(1):1–8. doi: 10.1261/rna.2121703 # Nuclear translation: What is the evidence? JAMES E DAHLBERG 1, ELSEBET LUND 1, ELIZABETH B GOODWIN 2 - Copyright and License information - Author information 1Department of Biomolecular Chemistry, 2Department of Genetics, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA Reprint requests to: James E. Dahlberg, Department of Biomolecular Chemistry, University of Wisconsin–Medical School, 1300 University Ave., Madison, WI 53706, USA; e-mail: dahlberg@wisc.edu. Copyright © Copyright 2003 by RNA Society PMC Copyright notice PMCID: PMC1370363 PMID: 12554869 ## Abstract Recently, several reports have been published in support of the idea that protein synthesis occurs in both the nucleus and the cytoplasm. This proposal has generated a great deal of excitement because, if true, it would mean that our thinking about the compartmentalization of cell functions would have to be re-evaluated. The significance and broad implications of this phenomenon require that the experimental evidence used to support it be carefully evaluated. Here, we critique the published evi