Yellow coat color in mice is linked to a lethal genetic mutation
the verdict
SUPPORTED
the evidence backs this
confidence 91/100
The lethal yellow (Ay) mutation in mice produces a yellow coat color in heterozygotes while being embryonically lethal in homozygotes, a well-documented genetic link established through molecular cloning of the agouti locus.
Evidence for · 5
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.
1993 · cited by 355
Explains that the lethal yellow (Ay) mutation causes the exclusive production of yellow pigment and pleiotropic effects including lethality.
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More for · 4
Mouse models of obesity.
2004 · cited by 0
Notes that the agouti mouse mutation results in obese, yellow mice, and the lethal yellow mutation is a classic genetic model.
Effects of the lethal yellow (Ay) mutation in mouse aggregation chimeras.
1990 · cited by 0
States that the Ay allele is a recessive lethal mutation at the mouse agouti locus and results in a yellow coat color in heterozygotes.
Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs.
1994 · cited by 0
Demonstrates that heterozygosity for the lethal yellow mutation leads to yellow coat color and pleiotropic effects, while homozygosity is embryonic lethal.
The agouti gene: turned on to yellow.
1994 · cited by 0
Summarizes that mutations at the murine agouti locus affect coat color as well as leading to embryonic lethality.