Untreated HIV leads to complete destruction of the adaptive immune system
Untreated HIV infection progressively depletes CD4+ T cells, ultimately resulting in severe immunodeficiency and AIDS.
The retrieved papers consistently confirm that untreated HIV infection causes progressive depletion and destruction of CD4+ T cells and overall immune dysregulation leading to AIDS, supporting the claim.
N. Chirmule, S. Pahwa. Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.. 1996. https://doi.org/10.1128/MMBR.60.2.386-406.1996
States that untreated HIV-1 infection leads to progressive destruction of the CD4+ T-cell subset and resulting immune deficiency.
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B. Poonia, D. Pauza, M. Salvato. Role of the Fas/FasL pathway in HIV or SIV disease. 2009. https://doi.org/10.1186/1742-4690-6-91
Explains how HIV disease involves progressive quantitative depletion of immune cell subsets, leading to immunodeficiency.
P. Verma, G. Shanmugam, S. Bansode. Challenges to Cure: Transmission, Virulence and Pathogenesis of HIV Infection. 2018. https://doi.org/10.21276/IJLSSR.2018.4.1.18
Highlights the hallmark of HIV infection as the progressive depletion of CD4 helper T cells resulting in reduced production and increased destruction.
Qiankun Wang, Liang Shan. The CARD8 inflammasome drives CD4 <sup>+</sup> T-cell depletion in HIV-1 infection. 2023. https://doi.org/10.1101/2023.03.18.533283
Demonstrates that CD4+ T-cell depletion is the root cause of acquired immunodeficiency syndrome (AIDS).
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