Type 2 diabetes mellitus is caused by insulin resistance and relative insulin deficiency
the verdict
SUPPORTED
the evidence backs this
confidence 97/100
Type 2 diabetes mellitus is primarily driven by a combination of peripheral insulin resistance and progressive pancreatic beta-cell dysfunction leading to relative insulin deficiency.
Evidence for · 4
Pathophysiology of Type 2 Diabetes Mellitus
2020 · cited by 3,243
Paper [0] states that type 2 diabetes mellitus is caused by defective insulin secretion from pancreatic beta cells and the inability of tissues to respond to insulin.
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More for · 3
Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
2017 · cited by 1,499
Paper [3] notes that impaired insulin secretion, resistance to tissue actions of insulin, or a combination of both contribute to the pathophysiology of T2DM.
The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus
2013 · cited by 653
Paper [5] explains that type 2 diabetes is caused by a combination of impaired insulin secretion and insulin resistance.
Revisiting Insulin Resistance in the Pathophysiology of Type 2 Diabetes Mellitus: A Multi-Organ Perspective.
2026 · cited by 0
Paper [9] highlights insulin resistance as a central pathophysiological driver of type 2 diabetes mellitus alongside metabolic disturbances.