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the claim
Tylenol PM can cause wakefulness in certain individuals
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

Tylenol PM contains diphenhydramine, an antihistamine that normally causes drowsiness but can paradoxically induce wakefulness or excitation in certain individuals.

Evidence for · 2
Paradoxical Excitation on Diphenhydramine May Be Associated with Being a CYP2D6 Ultrarapid Metabolizer:<i>Three Case Reports</i>
2008 · cited by 31
Diphenhydramine, the active sedating antihistamine in Tylenol PM, can occasionally cause paradoxical excitation in certain individuals.
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The analysis

The claim is supported by medical case reports demonstrating that diphenhydramine (the sedating component of Tylenol PM) can cause paradoxical excitation or wakefulness in susceptible individuals, such as ultrarapid metabolizers.

More for · 1
From sedation to stimulation: anecdotal case reports of enhanced sexual arousal in men and women taking diphenhydramine hydrochloride.
2026 · cited by 0
Case reports document unexpected stimulation and excitation responses to diphenhydramine instead of sedation.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8404 Aug 2026
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