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the claim
True Mendelian traits exist that do not display polygeny
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
7 sources for · 0 against

Multiple genetic and clinical studies confirm the existence of true Mendelian traits that follow single-gene inheritance patterns without a polygenic basis, such as monogenic disorders and specific phenotypic traits like earwax type.

Evidence for · 7
Genome editing as a tool to achieve the crop ideotype and de novo domestication of wild relatives: Case study in tomato.
2017 · cited by 142
Paper 0 notes that breeding is straightforward when traits are monogenic and show Mendelian inheritance, contrasting them with polygenic traits.
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The analysis

The claim states that true Mendelian traits exist that do not display polygeny. Numerous papers in the literature discuss monogenic Mendelian disorders and single-gene traits (such as the ABCC11 earwax polymorphism or familial chylomicronemia syndrome) as distinct from complex polygenic traits. All relevant papers support the existence of monogenic Mendelian inheritance. Therefore, the verdict is SUPPORTED.

More for · 6
Precision Medicine in Internal Medicine
2019 · cited by 17
Paper 2 notes that OMIA and OMIM database records document thousands of single-gene Mendelian disorders.
Monogenic and polygenic concepts in chronic kidney disease (CKD)
2023 · cited by 14
Paper 3 states that monogenic disorders account for substantial percentages of certain diseases, distinct from polygenic traits.
Equus in Online Mendelian Inheritance in Animals (OMIA)
2024 · cited by 12
Paper 5 highlights that OMIA focuses on Mendelian traits and their causal mutations in animals.
Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s
2019 · cited by 6
Paper 7 describes familial chylomicronemia syndrome as a monogenic disorder caused by mutations in single genes, contrasting with polygenic hypertriglyceridemia.
Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic clinicians.
2025 · cited by 3
Paper 9 notes that monogenic diseases result from pathogenic variants in a single gene with large effects, unlike polygenic diseases.
ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques.
2025 · cited by 2
Paper 11 demonstrates that the ABCC11 earwax phenotype is determined by a single-nucleotide polymorphism, providing a clear example of a Mendelian trait without polygeny.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8804 Aug 2026
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