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the claim
Transcription factors bind to both strands of DNA
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

Evidence shows that transcription factors can make strand-specific contacts and even bridge across multiple DNA strands.

Evidence for · 2
DNA methylation shapes transcription factor binding beyond canonical CpG contexts.
2025 · cited by 0
Paper [3] demonstrates that transcription factor sensitivity to DNA modifications varies by strand orientation, highlighting interactions that span distinct strands.
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The analysis

The retrieved literature includes studies showing transcription factor sensitivity to strand-specific contexts (such as hemimethylation) and multi-strand interactions like DNA bridging by multimeric transcription factors, thereby supporting the claim.

More for · 1
FOXP3 recognizes microsatellites and bridges DNA through multimerization.
2023 · cited by 0
Paper [5] shows that transcription factors such as FOXP3 can bridge across two double-stranded DNA molecules, interacting with multiple strands simultaneously.
The paper trail · every fact has a biography
first checked31 Jul 2026
judged → SUPPORTED · 7531 Jul 2026
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