Evidence shows that transcription factors can make strand-specific contacts and even bridge across multiple DNA strands.
Evidence for · 2
DNA methylation shapes transcription factor binding beyond canonical CpG contexts.
2025 · cited by 0
Paper [3] demonstrates that transcription factor sensitivity to DNA modifications varies by strand orientation, highlighting interactions that span distinct strands.
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More for · 1
FOXP3 recognizes microsatellites and bridges DNA through multimerization.
2023 · cited by 0
Paper [5] shows that transcription factors such as FOXP3 can bridge across two double-stranded DNA molecules, interacting with multiple strands simultaneously.