Trans fatty acids have negative health effects on humans
Substantial scientific literature, including systematic reviews, clinical studies, and global health surveillance, demonstrates that trans fatty acids have negative health effects, particularly increasing the risk of cardiovascular disease, inflammation, and mortality.
The claim is specific, empirical, and contestable in historical context, but overwhelming scientific consensus and recent meta-analyses strongly support the negative health effects of trans fats.
Russell J de Souza, Andrew Mente, Adriana Maroleanu, Adrian I Cozma, Vanessa Ha, Teruko Kishibe, Elizabeth Uleryk, Patrick Budylowski, Holger Schünemann, Joseph Beyene, Sonia S Anand. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies.. 2015. https://doi.org/10.1136/bmj.h3978
A systematic review and meta-analysis shows that trans fat intake is associated with increased all-cause mortality, coronary heart disease mortality, and total coronary heart disease.
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Mateusz M Wilczek, Robert Olszewski, Andrzej Krupienicz. Trans-Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation.. 2017. https://doi.org/10.1159/000479956
This study notes that high trans-fatty acid intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease incidence.
Mateusz M Wilczek, Robert Olszewski, Andrzej Krupienicz. [Cardiovascular disease and trans fatty acids: legal act necessary].. 2018. https://pubmed.ncbi.nlm.nih.gov/29498371/
The paper reiterates that high trans-fatty acid intake is linked to increased all-cause mortality and cardiovascular disease incidence.
Chaoyang Li, Laura K Cobb, Hubert W Vesper, Samira Asma. Global Surveillance of trans-Fatty Acids.. 2019. https://doi.org/10.5888/pcd16.190121
Global surveillance data indicates that trans-fatty acid intake can increase the risk of coronary heart disease morbidity, mortality, and all-cause mortality.
J Edward Hunter, Jun Zhang, Penny M Kris-Etherton. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review.. 2010. https://doi.org/10.3945/ajcn.2009.27661
The review notes that trans fatty acid intake should be reduced as much as possible because of its adverse effects on lipids and lipoproteins.
A M Salter. Dietary fatty acids and cardiovascular disease.. 2013. https://doi.org/10.1017/S1751731111002023
Reviews highlight the potent adverse effects of trans fatty acids derived from partially hydrogenated vegetable oil on cardiovascular health.
Dariush Mozaffarian. Trans fatty acids - effects on systemic inflammation and endothelial function.. 2006. https://doi.org/10.1016/j.atherosclerosissup.2006.04.007
Evidence indicates that trans fatty acids are pro-inflammatory and predict higher risk of coronary heart disease and sudden death.
Esther Lopez-Garcia, Matthias B Schulze, James B Meigs, JoAnn E Manson, Nader Rifai, Meir J Stampfer, Walter C Willett, Frank B Hu. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.. 2005. https://doi.org/10.1093/jn/135.3.562
A clinical study found that higher trans fatty acid intake adversely affects endothelial function and plasma biomarkers of inflammation.
Renata Micha, Dariush Mozaffarian. Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes.. 2009. https://doi.org/10.1038/nrendo.2009.79
The review outlines how trans-fatty acid consumption causes metabolic dysfunction, triggers systemic inflammation, and increases coronary heart disease risk.
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