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the claim
Topologically associating domains are structural units of genome folding
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
14 sources for · 1 against

Multiple peer-reviewed studies and authoritative references consistently establish that topologically associating domains (TADs) are structural and organizational units of three-dimensional genome folding.

Evidence for · 14
Wikipedia: Topologically associating domain
cited by 0
Reference article covering this claim directly
Evidence against · 1
ebi.ac.uk: Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. — instance of
cited by 0
Notes that TADs depend on cohesin and are regulated by CTCF.
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How claims like this are judged

Judged against reference works: claims of this kind are settled by reference works, not journal abstracts.

More for · 13
Academic Press: Nuclear matrix : structural and functional organization
1995 · cited by 0
Discusses DNA loops as basic units of genome organization.
PLoS Computational Biology: MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.
2017 · cited by 0
States that eukaryotic genomes are organized into structural units called topologically associating domains.
Frontiers in Cell and Developmental Biology: Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspective
2021 · cited by 0
Explicitly states that TADs are the structural units of chromatin and 3D genome organization.
PLoS Genetics: Induction of a chromatin boundary in vivo upon insertion of a TAD border.
2021 · cited by 0
Describes mammalian genomes partitioned into TADs functioning as structural scaffolds.
Nature Communications: DiffDomain enables identification of structurally reorganized topologically associating domains
2024 · cited by 0
Identifies TADs as critical structural units in three-dimensional genome organization.
Genome Biology: OnTAD: hierarchical domain structure reveals the divergence of activity among TADs and boundaries
2019 · cited by 0
References TADs as domains within which regulatory interactions occur.
Journal of Integrative Agriculture: 3D genome organization and its study in livestock breeding
2024 · cited by 0
Lists TADs as multiscale structural units of the eukaryotic genome.
OpenAIRE: Measuring the three-dimensional structural properties of topologically associating domains
2018 · cited by 0
Notes TADs are genomic regions that serve as structural and functional units.
OpenAIRE: Uncovering topologically associating domains from three-dimensional genome maps with TADGATE
2024 · cited by 0
Describes TADs as essential components of 3D genome organization.
OpenAIRE: SuperTAD: robust detection of hierarchical topologically associated domains with optimized structural information
2021 · cited by 0
States TADs are organizational units of chromosome structures.
OpenAIRE: Topologically associating domains are stable units of replication-timing regulation
2014 · cited by 0
Discusses TADs as conserved domains within chromatin architecture.
OpenAIRE: Topologically associating domains and their role in the evolution of genome structure and function in Drosophila
2020 · cited by 0
Describes TADs as fundamental units of three-dimensional eukaryotic genomic organization.
OpenAIRE: TADs: Dynamic structures to create stable regulatory functions
2023 · cited by 0
States TADs are structural units of 3D genome organization.
Everything we examined (25) — 19 independent sources
This check searched the claim as stated. It did not run a separate search for evidence against it.
  1. Wikipedia: Topologically associating domainreferencesupports
  2. Book: Vertebrate Skeletal Developmentreferencesame source L2supportsnot shown: a book whose author and subject did not establish authority here
  3. Book: Physical Data II / Physikalische Daten IIreferencesame source L3no side takennot shown: read and judged not to bear on this claim
  4. Book: Immunopharmacology of Lymphocytesreferencesame source L2no side takennot shown: read and judged not to bear on this claim
  5. ebi.ac.uk: Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. — instance ofreferencerefutes
  6. ASM Press: Principles of virology : molecular biology, pathogenesis, and controlreferenceno side takennot shown: read and judged not to bear on this claim
  7. Springer: Data mining in biomedicinereferencesame source L3no side takennot shown: read and judged not to bear on this claim
  8. Bios Scientific Publishers: Advanced molecular biology : a concise referencereferenceno side takennot shown: read and judged not to bear on this claim
  9. Cold Spring Harbor Laboratory: Evolution of catalytic functionreferencesame source L7no side takennot shown: read and judged not to bear on this claim
  10. Biological Laboratory: Cold Spring Harbor symposia on quantitative biologyreferencesame source L7no side takennot shown: read and judged not to bear on this claim
  11. Biological Laboratory: Cold Spring Harbor symposia on quantitative biologyreferencesame source L7no side takennot shown: read and judged not to bear on this claim
  12. Cold Spring Harbor Laboratory Press: DNA and chromosomesreferencesame source L7no side takennot shown: read and judged not to bear on this claim
  13. Academic Press: Nuclear matrix : structural and functional organizationreferencesame source L2supports
  14. PLoS Computational Biology: MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.peer-reviewedsupports
  15. Frontiers in Cell and Developmental Biology: Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspectivepeer-reviewedsupports
  16. PLoS Genetics: Induction of a chromatin boundary in vivo upon insertion of a TAD border.peer-reviewedsupports
  17. Nature Communications: DiffDomain enables identification of structurally reorganized topologically associating domainspeer-reviewedsupports
  18. Genome Biology: OnTAD: hierarchical domain structure reveals the divergence of activity among TADs and boundariespeer-reviewedsupports
  19. Journal of Integrative Agriculture: 3D genome organization and its study in livestock breedingpeer-reviewedsupports
  20. OpenAIRE: Measuring the three-dimensional structural properties of topologically associating domainspeer-reviewedsupports
  21. OpenAIRE: Uncovering topologically associating domains from three-dimensional genome maps with TADGATEpeer-reviewedsupports
  22. OpenAIRE: SuperTAD: robust detection of hierarchical topologically associated domains with optimized structural informationpeer-reviewedsupports
  23. OpenAIRE: Topologically associating domains are stable units of replication-timing regulationpeer-reviewedsupports
  24. OpenAIRE: Topologically associating domains and their role in the evolution of genome structure and function in Drosophilapeer-reviewedsupports
  25. OpenAIRE: TADs: Dynamic structures to create stable regulatory functionspeer-reviewedsupports
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first checked06 Aug 2026
judged → SUPPORTED · 5806 Aug 2026
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