Topical tacrolimus cream absorption can lead to systemic tacrolimus toxicity
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Evidence demonstrates that topical tacrolimus can be absorbed systemically, particularly when applied to compromised or diseased skin barriers, creating a potential risk for systemic adverse effects.
Evidence for · 3
Systemic absorption of topical tacrolimus in Pyoderma gangrenosum
2006 · cited by 11
Demonstrates that topical tacrolimus can lead to systemic absorption in clinical settings like pyoderma gangrenosum.
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More for · 2
Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.
2016 · cited by 7
Shows that compromised skin barriers and altered physiology increase systemic absorption of topical tacrolimus, creating a risk for side effects.
Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers.
2016 · cited by 2
Confirms that topical tacrolimus can be absorbed systemically when applied to compromised skin conditions such as skin ulcers.