Topical tacrolimus cream absorption can lead to systemic tacrolimus toxicity
Evidence demonstrates that topical tacrolimus can be absorbed systemically, particularly when applied to compromised or diseased skin barriers, creating a potential risk for systemic adverse effects.
Papers 0, 1, and 6 provide direct evidence that topical application of tacrolimus can lead to measurable systemic absorption, especially when the skin barrier is disrupted or diseased. No papers refute the claim.
G Pitarch, A Torrijos, L Mahiques, JL Sánchez-Carazo, JM. Fortea. Systemic absorption of topical tacrolimus in Pyoderma gangrenosum. 2006. https://doi.org/10.1080/00015550510040923
Demonstrates that topical tacrolimus can lead to systemic absorption in clinical settings like pyoderma gangrenosum.
See more details
Yutaro Hazama, Toshihisa Maekawa, R. Miki, S. Oshima, Yuya Egawa, K. Morimoto, T. Seki. Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.. 2016. https://doi.org/10.1248/bpb.b15-00727
Shows that compromised skin barriers and altered physiology increase systemic absorption of topical tacrolimus, creating a risk for side effects.
R. García-Delgado, E. Escario-Travesedo, A. Sánchez-Romero. Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers.. 2016. https://doi.org/10.1016/j.ad.2016.05.010
Confirms that topical tacrolimus can be absorbed systemically when applied to compromised skin conditions such as skin ulcers.
The paper trail · every fact has a biography
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work · Dispute this receipt