Topical steroid withdrawal is related to secondary adrenal insufficiency
the verdict
SUPPORTED
the evidence backs this
confidence 78/100
Multiple case reports and clinical studies indicate that chronic or excessive use of topical corticosteroids can suppress the hypothalamic-pituitary-adrenal axis, leading to secondary adrenal insufficiency and potential crisis upon withdrawal.
Discusses diagnosing and differentiating topical steroid withdrawal from other causes of adrenal insufficiency.
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More for · 4
Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency in a Child due to Topical Ocular Corticosteroids: A Case Report
2025 · cited by 2
Describes a case of iatrogenic Cushing's syndrome and secondary adrenal insufficiency caused by topical ocular corticosteroid treatment.
A case of Hailey-Hailey disease accompanied by Cushing's syndrome and adrenal insufficiency due to long-term usage of topical steroids with review of literature.
2025 · cited by 1
Notes that prolonged topical steroid use can lead to HPA axis suppression and adrenal insufficiency during withdrawal.
Mometasone Furoate–Induced Iatrogenic Cushing's Syndrome and Secondary Adrenal Insufficiency: A Case Report
2025 · cited by 1
Reports a pediatric case of iatrogenic Cushing's syndrome and secondary adrenal insufficiency due to prolonged topical corticosteroid administration.
Cushingoid Features and Addisonian Crisis Following Abrupt Withdrawal of Potent Topical Corticosteroids: A Case Report.
2025 · cited by 0
Highlights how abrupt withdrawal of long-term potent topical corticosteroids can precipitate an Addisonian crisis due to underlying adrenal suppression.