Clinical and in vitro studies support replacing toothbrushes every 2 to 3 months, as bristle flaring and wear after this period significantly reduce plaque removal efficacy.
The retrieved literature contains direct empirical evidence investigating the effect of toothbrush wear and lifespan on plaque removal efficacy. Papers [8] and [9] specifically examine toothbrush replacement intervals, finding that bristle wear and flaring begin to negatively impact plaque removal after approximately 2 to 3 months of use, directly supporting the claim. No papers contradict this timeline.