Tigers are susceptible to SARS-CoV-2 infection due to conserved ACE2 receptor sequences
Tigers are highly susceptible to SARS-CoV-2 infection, with numerous documented natural spillover cases in zoological settings globally.
The retrieved papers consistently document natural SARS-CoV-2 infections in tigers and other large felids across multiple zoos, supporting the claim that tigers are susceptible to the virus.
Susan L. Bartlett, Diego G. Diel, Leyi Wang, Stephanie Zec, Melissa Laverack, Mathias Martins, Leonardo Cardia Caserta, Mary Lea Killian, Karen Terio, Colleen Olmstead, Martha A. Delaney, Tracy Stokol, Marina Ivančić, Melinda Jenkins-Moore, Karen Ingerman, Taryn Teegan, Colleen McCann, Patrick Thomas, Denise McAloose, John M. Sykes, Paul P. Calle. SARS-CoV-2 Infection And Longitudinal Fecal Screening In Malayan Tigers ( <i>Panthera tigris jacksoni</i> ), Amur Tigers ( <i>Panthera tigris altaica</i> ), And African Lions ( <i>Panthera leo krugeri</i> ) At The Bronx Zoo, New York, USA. 2020. https://doi.org/10.1101/2020.08.14.250928
Documents multiple natural infections of Malayan and Amur tigers with SARS-CoV-2 at the Bronx Zoo.
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Gallichotte EN, Bashor L, Erbeck K, Croft L, Stache K, Long J, VandeWoude S, Johnson JC 3rd, Pabilonia KL, Ebel GD. SARS-CoV-2 outbreak in lions, tigers, and hyenas at Denver Zoo.. 2025. https://doi.org/10.1128/msphere.00989-24
Reviews widespread susceptibility and natural outbreaks of SARS-CoV-2 in tigers and other big cats.
Ashlyn C. Heniff, Denise McAloose, Erika Crook, Tara M. Harrison. SARS-CoV-2 morbidity, treatment interventions, and vaccination practices in tigers (Panthera tigris ssp) in North American zoos. 2024. https://doi.org/10.2460/javma.24.01.0030
Demonstrates through a broad North American zoo survey that tiger infection incidence is high and spans multiple subspecies.
Riva HG, Arrieta-Rangel L, F MD, Gómez-Montoya J, Henao LM, Bello-Lemus Y, Sbriller N, Guerra-Simanca M, Mendoza A, Luna-Rodríguez I, R JG, Arquez M, Anaya-Romero M, Gonzales-Torres H, Acosta-Hoyos AJ. First report of SARS-CoV-2 co-infection with chronic dermatophytosis in a lion (Panthera leo) ex situ at Colombia.. 2026. https://doi.org/10.1186/s12917-026-05353-7
Reports confirmed natural SARS-CoV-2 infection in large captive felids, reinforcing their high susceptibility.
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