Thyroid-stimulating hormone levels vary significantly over the course of a day

the verdict

SUPPORTED

the evidence backs this

Recorded sources

4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Thyroid-stimulating hormone (TSH) levels exhibit robust, statistically significant diurnal variation over the course of a day, typically peaking overnight and reaching lower levels in the afternoon.

The analysis

The claim that TSH levels vary significantly over the course of a day is well-supported by multiple retrieved papers demonstrating circadian and diurnal rhythms of TSH in both human and animal studies (e.g., papers 2, 4, 6, and 11). There is no evidence refuting this physiological fact.

Evidence for · 4

Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat

Recorded source metadata

B. Stringer, D. Wynford-Thomas, B. Jasani, E. D. Williams. Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat. 1981. https://doi.org/10.1530/acta.0.0980396

Demonstrates a significant diurnal rhythm of serum TSH in animal models independent of peripheral thyroid hormones.

Source citation format

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More for · 3

Diurnal fluctuations in thyroid hormones - the Bispebjerg study of diurnal variations.

Recorded source metadata

Rabab BZ, Jensen CZ, Jørgensen HL, Sennels HP. Diurnal fluctuations in thyroid hormones - the Bispebjerg study of diurnal variations.. 2026. https://doi.org/10.1080/00365513.2026.2659592

Shows statistically significant diurnal variation of TSH in humans, peaking at 2 AM and varying substantially over 24 hours.

Source citation format

Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration.

Recorded source metadata

Meristoudis G, Savvidis C, Ilias I. Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration.. 2025. https://doi.org/10.5493/wjem.v15.i4.110893

Highlights the circadian rhythm of TSH, which peaks overnight and is relevant for clinical treatment timing.

Source citation format

PBK Modeling of Thyroid Hormone Circadian Rhythm: Elucidating Thyroidal and Extrathyroidal Contributions to Thyroid Hormone Chronobiology

Recorded source metadata

Anish Bagga, Qiang Zhang. PBK Modeling of Thyroid Hormone Circadian Rhythm: Elucidating Thyroidal and Extrathyroidal Contributions to Thyroid Hormone Chronobiology. 2025. https://doi.org/10.1152/physiol.2025.40.s1.1969

Describes the robust circadian pattern and daily oscillations of TSH regulated by the hypothalamic-pituitary-thyroid axis.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 8001 Aug 2026

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