There is a quantitative expression for steric hindrance
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Quantitative expressions and descriptors for steric hindrance, such as Tolman's cone angle and computational estimation tools, are well established in chemistry to model molecular interactions.
Evidence for · 3
Dual Effect of Steric Hindrance in Non-Aqueous Amine Absorbents: Navigating the Trade-Off Between Kinetics and Thermodynamics for Efficient CO<sub>2</sub> Capture.
2026 · cited by 0
Introduces molecular descriptors to quantify steric hindrance and links them to performance via QSAR analyses.
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More for · 2
Application of statistical design of experiment to identify key factors in cross coupling reactions.
2025 · cited by 0
Utilizes quantitative metrics like Tolman's cone angle to evaluate steric effects in ligands for cross-coupling reactions.
STRIDER: Steric hindrance estimator
2020 · cited by 0
Provides a computational web tool (STRIDER) to estimate and report pairwise steric hindrances using atomic radii.