There is a direct relationship between vitamin D levels and cholesterol
Current clinical and observational evidence largely supports a relationship between vitamin D levels and lipid profiles, with deficiencies frequently correlating with adverse cholesterol and triglyceride parameters.
Multiple large-scale studies, clinical trials, and reviews indicate meaningful associations between serum 25-hydroxyvitamin D levels and cholesterol/lipid parameters, though some specific populations show weak or varying correlations.
Fuentes-Barría H, Aguilera-Eguía R, Alarcón-Rivera M, Angarita-Davila L, Flores-Fernández C. Vitamin D and Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms and Clinical Implications-A Narrative Review.. 2026. https://doi.org/10.3390/ijms27062532
This review highlights that vitamin D influences lipid homeostasis and that supplementation can improve lipid parameters in metabolic liver disease.
Rana R, Adhikari P, Kamath U, Shastri BA, Umakanth S, Maiya GA, Rao S R, Lakshmi R V, Kamath SU. Triglyceride-glucose-based indices in relation to vitamin D concentrations among adults with metabolic syndrome.. 2026. https://doi.org/10.1371/journal.pone.0349683
A study in metabolic syndrome patients found that the association between glucose-lipid indices and vitamin D is weak and of limited clinical relevance.
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Saad Alfawaeir. Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency. 2025. https://doi.org/10.12873/453alfawaeir
A prospective study demonstrating that vitamin D supplementation significantly alters and correlates with serum lipid profiles.
Groesser V, Most A, Sedighi J, Böttger P, Sossalla S, Bauer P. Vitamin D Status and Atherogenic Lipid Profiles, Including Lipoprotein(a), in Elite Athletes.. 2026. https://doi.org/10.3390/nu18122013
Research in elite athletes shows independent associations between higher vitamin D concentrations and more favorable, lower atherogenic lipid profiles.
Şahin F, Saral NY, Toker A, Tay İ, Tekin N, Serteser M, Baykal AT. Association between serum vitamin D levels and atherogenic lipid subfractions: insights from NMR-based lipid profiling in a large adult population.. 2026. https://doi.org/10.1038/s41598-026-42349-7
A large-scale NMR-based population study found vitamin D deficiency is independently associated with an atherogenic dyslipidemia and specific lipoprotein subfractions.
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