There are valid metrics for measuring the overall excitation of the central nervous system
Multiple clinical and neurophysiological studies confirm that metrics such as electroencephalography (EEG), event-related potentials (ERPs), and electroretinography (ERG) provide valid and quantifiable measures of central nervous system arousal and excitation.
The claim asserts that there are valid metrics for measuring the overall excitation of the central nervous system. A wide range of high-quality neurophysiological literature, including studies utilizing EEG, ERPs, ERG, and evoked potentials, directly supports the validity of these metrics for quantifying CNS arousal, excitation-inhibition balance, and neurological function. Therefore, the verdict is SUPPORTED with no refuting papers.
P. Constable, Jeremiah K. H. Lim, D. Thompson. Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies. 2023. https://doi.org/10.3389/fnins.2023.1215097
Paper [0] discusses functional retinal biomarkers and electroretinography as valid physiological indicators for assessing central nervous system function and pathology.
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A. Bradbury, J. Bagel, Xuntian Jiang, Gary P. Swain, Maria Prociuk, C. Fitzgerald, Patricia Odonnell, Kyle G. Braund, D. Ory, C. Vite. Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe disease). 2016. https://doi.org/10.1002/jnr.23838
Paper [1] demonstrates that electrophysiological metrics like auditory-evoked responses and nerve conduction velocities provide quantifiable, valid measures of central nervous system disease progression.
Da-Wei Zhang, S. Johnstone, S. Roodenrys, Xiangsheng Luo, Hui Li, Encong Wang, Qihua Zhao, Yan Song, Lu Liu, Q. Qian, Yufeng Wang, Li Sun. The role of resting-state EEG localized activation and central nervous system arousal in executive function performance in children with Attention-Deficit/Hyperactivity Disorder.. 2018. https://doi.org/10.1016/j.clinph.2018.03.009
Paper [2] uses resting-state electroencephalogram (RS-EEG) spectral power and alpha band activity as valid metrics for measuring central nervous system arousal and activation.
Xue-wei Chen, Liwei Zhang, Danfeng Yang, Chao Li, G. An, Jing Wang, Yongcong Shao, R. Fan, Q. Ma. Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation. 2020. https://doi.org/10.3389/fnbeh.2020.00108
Paper [3] employs event-related potentials (ERPs) and electroencephalography to measure changes in central nervous system arousal and cognitive efficiency following caffeine and sleep deprivation.
Loïs S Miraucourt, M. Accardi, K. Asin, M. Pugsley, M. Curtis, S. Authier. The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system.. 2020. https://doi.org/10.1016/j.vascn.2020.106883
Paper [5] validates in vitro electrophysiological recordings of AMPA receptor currents as reliable readouts for assessing central nervous system pharmacology and drug-induced alterations.
Senqi Liu, Yujuan Zhang, Kang Liu, Xiaoge Guo, Jinming Li, Ranran Li, Yongfeng Yang, Jing-yuan Zhao, Jianhong Zhang, Xiujuan Wang, Shuang Ding, Binbin Luo, Yong Han, Luwen Zhang, Luxian Lv, X. Su. Robo2-Nrxn3 Deficiency: A Molecular Hub Linking Excitation-Inhibition Imbalance to the Pathogenesis of Schizophrenia.. 2026. https://doi.org/10.1093/schbul/sbag005
Paper [8] links neurophysiological measures such as event-related potentials and cortical activation to central nervous system excitation-inhibition balance in clinical and animal models.
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