The time until a drug reaches steady-state is calculated using its elimination half-life
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Pharmacokinetic principles establish that the time required for a drug to reach steady-state is determined by its elimination half-life, typically taking about four to five half-lives to achieve.
Evidence for · 4
Introduction to Pharmacokinetic Analysis—Focus on Phase I Study—
2015 · cited by 0
Paper 3 states that steady state is generally considered to be reached at a time equal to five times the elimination half-life of a drug.
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More for · 3
Estimation of Attainment of Steady-State Conditions for Compounds With a Long Half-Life.
2021 · cited by 0
Paper 4 notes that the time to attainment of steady-state conditions is generally derived from the terminal half-life.
Pharmacokinetics of antiepileptic drugs.
1998 · cited by 0
Paper 5 explains that determination of the elimination half-life provides a basis for predicting the time to steady-state concentration.
Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age.
2007 · cited by 0
Paper 11 demonstrates the application of pharmacokinetic principles where steady-state conditions and accumulation are calculated based on the biological half-life.