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the claim
The tert-butyl group directs electrophilic aromatic substitution primarily to the ortho and para positions.
the verdict
COMMON KNOWLEDGE
no citation needed for this one
refutedsupported
the weight of evidence
no sources on either side

The directing effect of alkyl groups such as the tert-butyl group in electrophilic aromatic substitution is a fundamental chemical principle found in standard textbooks, making formal citation unnecessary.

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The analysis

The claim states a standard chemical rule regarding the directing effects of alkyl groups in electrophilic aromatic substitution, which is a matter of common chemical knowledge taught in organic chemistry.

Everything we examined (12)
  1. Recent Advances in Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. High Site Selectivity in Electrophilic Aromatic Substitutions: Mechanism of C-H Thianthrenation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Copper‐Catalyzed Chelation‐Assisted <i>ortho</i>‐Nitration of 2‐Aryls Using Pharmacophoric Benzothiazoles and Benzoxazoles as Directing Groupspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Catalytic Enantioselective Methods for Synthesis of 1,2-Amino Tertiary Alcohols and Their Analogues.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Amines tuned controllable carbonylation for the synthesis of γ-lactones and 1,4-diones.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Electrophilic aromatic substitutionpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Chemistry of 1,2‐di‐<i>tert.</i>Butylbenzene and derivatives i. nitration of 1,2‐di‐<i>tert.</i>butylbenzenepeer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Hydrazone-schiff base derivatives of 4-(tert-butyl)benzoic acid as potent enzyme inhibitors: In vitro α-amylase, α-glucosidase, tyrosinase inhibition and computational studies.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Steroidal Compounds at the Crossroads of Inflammation and Cancer: Implications for Drug Discovery and Therapy.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Fluorinated terpenoids and their fluorine-containing derivatives.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Strain-Release Induced 1,2-Metallate Rearrangement of Geminal Diborons: Multicomponent 1,5-Difunctionalization via Ring-Opening Coupling.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → COMMON KNOWLEDGE · 9505 Aug 2026
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