The term prion describes both the normal cellular protein and its disease-causing form
the verdict
SUPPORTED
the evidence backs this
confidence 87/100
The retrieved literature consistently supports the scientific definition that the term prion encompasses both the normal cellular protein (PrPC) and its disease-causing isoform (PrPSc).
Evidence for · 3
PrPSc-like prion protein peptide inhibits the function of cellular prion protein
2000 · cited by 76
The paper discusses the normal cellular prion protein and its role in disease.
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More for · 2
Species differences in the blood content of the normal cellular isoform of prion protein, PrP<sup>c</sup>, measured by time‐resolved fluoroimmunoassay
2001 · cited by 16
The paper distinguishes the normal cellular isoform, PrPC, from the abnormal form associated with infectivity.
Spontaneous conformational change within the prion protein—implications for disease pathogenesis?
2001 · cited by 1
The paper notes the conversion of host prion protein, PrPC, into the disease-causing form, PrPSc.